FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059564304> ?p ?o ?g. }

• W2059564304 endingPage "1730" @default.
• W2059564304 startingPage "1724" @default.
• W2059564304 abstract "PEGylation of recombinant adenovirus (Ad) vectors is a promising approach for not only evasion from neutralizing anti-Ad antibodies and uptake by phagocytic cells, but also prolongation of the blood retention time of Ad vectors after systemic administration. However, the conventional PEGylation leads to significant reduction in the transduction activity of Ad vectors, probably because PEG is nonspecifically conjugated to the Ad capsid protein and inhibits the binding of Ad vectors to the primary receptor, coxsackievirus-adenovirus receptor (CAR). In order to PEGylate an Ad vector without significant reduction in the transduction activity, the biotin-binding peptide (BAP) was inserted into the hypervariable region (HVR) 5 of the hexon, which is not involved in the binding to CAR, and PEG was then specifically conjugated to the hexon HVR5 via avidin-biotin interaction. In vitro transduction experiments demonstrated that the hexon-specific PEGylation did not cause an apparent reduction in the transduction efficiency of the Ad vector, although the insertion of the BAP into the HVR5 itself reduced the transduction efficiency by 50-fold, compared with the conventional Ad vector, in the absence of anti-Ad serum. In the presence of anti-Ad serum, the transduction with the Ad vector with the BAP in the hexon HVR5 was significantly blocked; however, anti-Ad serum only slightly inhibited the transduction with the hexon-specifically PEGylated Ad vector (Ad-BAP/Bio/Avi/Bio-PEG-L2). Intravenous administration of Ad-BAP/Bio/Avi/Bio-PEG-L2 resulted in prolonged blood retention, significant reduction in the transduction in the liver, and accumulation in the tumor; however, unexpectedly, the transduction efficiency of Ad-BAP/Bio/Avi/Bio-PEG-L2 in the tumor was almost at the background level." @default.
• W2059564304 created "2016-06-24" @default.
• W2059564304 creator A5011332257 @default.
• W2059564304 creator A5011409446 @default.
• W2059564304 creator A5021383043 @default.
• W2059564304 creator A5027203010 @default.
• W2059564304 creator A5029199190 @default.
• W2059564304 creator A5047352896 @default.
• W2059564304 creator A5072978499 @default.
• W2059564304 creator A5079742854 @default.
• W2059564304 date "2011-02-01" @default.
• W2059564304 modified "2023-09-27" @default.
• W2059564304 title "Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction" @default.
• W2059564304 cites W1594450556 @default.
• W2059564304 cites W1970288095 @default.
• W2059564304 cites W1980775178 @default.
• W2059564304 cites W1982805293 @default.
• W2059564304 cites W1984558904 @default.
• W2059564304 cites W1993408035 @default.
• W2059564304 cites W1999982139 @default.
• W2059564304 cites W2000620796 @default.
• W2059564304 cites W2011733836 @default.
• W2059564304 cites W2012714016 @default.
• W2059564304 cites W2021643186 @default.
• W2059564304 cites W2026544727 @default.
• W2059564304 cites W2029175314 @default.
• W2059564304 cites W2041497601 @default.
• W2059564304 cites W2043346515 @default.
• W2059564304 cites W2046135645 @default.
• W2059564304 cites W2064074518 @default.
• W2059564304 cites W2065770997 @default.
• W2059564304 cites W2068343030 @default.
• W2059564304 cites W2079523736 @default.
• W2059564304 cites W2083553600 @default.
• W2059564304 cites W2098866087 @default.
• W2059564304 cites W2106100179 @default.
• W2059564304 cites W2111754083 @default.
• W2059564304 cites W2122171046 @default.
• W2059564304 cites W2140376045 @default.
• W2059564304 cites W2146108709 @default.
• W2059564304 cites W2154853039 @default.
• W2059564304 cites W2162013743 @default.
• W2059564304 cites W2164806280 @default.
• W2059564304 cites W2167429078 @default.
• W2059564304 cites W2313843498 @default.
• W2059564304 cites W2314038177 @default.
• W2059564304 cites W2322389503 @default.
• W2059564304 doi "https://doi.org/10.1016/j.biomaterials.2010.10.060" @default.
• W2059564304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21106235" @default.
• W2059564304 hasPublicationYear "2011" @default.
• W2059564304 type Work @default.
• W2059564304 sameAs 2059564304 @default.
• W2059564304 citedByCount "15" @default.
• W2059564304 countsByYear W20595643042012 @default.
• W2059564304 countsByYear W20595643042013 @default.
• W2059564304 countsByYear W20595643042014 @default.
• W2059564304 countsByYear W20595643042015 @default.
• W2059564304 countsByYear W20595643042016 @default.
• W2059564304 countsByYear W20595643042020 @default.
• W2059564304 countsByYear W20595643042022 @default.
• W2059564304 crossrefType "journal-article" @default.
• W2059564304 hasAuthorship W2059564304A5011332257 @default.
• W2059564304 hasAuthorship W2059564304A5011409446 @default.
• W2059564304 hasAuthorship W2059564304A5021383043 @default.
• W2059564304 hasAuthorship W2059564304A5027203010 @default.
• W2059564304 hasAuthorship W2059564304A5029199190 @default.
• W2059564304 hasAuthorship W2059564304A5047352896 @default.
• W2059564304 hasAuthorship W2059564304A5072978499 @default.
• W2059564304 hasAuthorship W2059564304A5079742854 @default.
• W2059564304 hasConcept C104317684 @default.
• W2059564304 hasConcept C15152581 @default.
• W2059564304 hasConcept C153911025 @default.
• W2059564304 hasConcept C159047783 @default.
• W2059564304 hasConcept C185592680 @default.
• W2059564304 hasConcept C202878990 @default.
• W2059564304 hasConcept C2522874641 @default.
• W2059564304 hasConcept C2776954459 @default.
• W2059564304 hasConcept C2776964284 @default.
• W2059564304 hasConcept C2779149719 @default.
• W2059564304 hasConcept C32470452 @default.
• W2059564304 hasConcept C40767141 @default.
• W2059564304 hasConcept C55493867 @default.
• W2059564304 hasConcept C86803240 @default.
• W2059564304 hasConcept C95444343 @default.
• W2059564304 hasConceptScore W2059564304C104317684 @default.
• W2059564304 hasConceptScore W2059564304C15152581 @default.
• W2059564304 hasConceptScore W2059564304C153911025 @default.
• W2059564304 hasConceptScore W2059564304C159047783 @default.
• W2059564304 hasConceptScore W2059564304C185592680 @default.
• W2059564304 hasConceptScore W2059564304C202878990 @default.
• W2059564304 hasConceptScore W2059564304C2522874641 @default.
• W2059564304 hasConceptScore W2059564304C2776954459 @default.
• W2059564304 hasConceptScore W2059564304C2776964284 @default.
• W2059564304 hasConceptScore W2059564304C2779149719 @default.
• W2059564304 hasConceptScore W2059564304C32470452 @default.
• W2059564304 hasConceptScore W2059564304C40767141 @default.
• W2059564304 hasConceptScore W2059564304C55493867 @default.
• W2059564304 hasConceptScore W2059564304C86803240 @default.

• next