Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059564760> ?p ?o ?g. }
- W2059564760 endingPage "60" @default.
- W2059564760 startingPage "1" @default.
- W2059564760 abstract "Developing recombinant protein pharmaceuticals has proved to be very challenging because of both the complexity of protein production and purification, and the limited physical and chemical stability of proteins. To overcome the instability barrier, proteins often have to be made into solid forms to achieve an acceptable shelf life as pharmaceutical products. The most commonly used method for preparing solid protein pharmaceuticals is lyophilization (freeze-drying). Unfortunately, the lyophilization process generates both freezing and drying stresses, which can denature proteins to various degrees. Even after successful lyophilization with a protein stabilizer(s), proteins in solid state may still have limited long-term storage stability. In the past two decades, numerous studies have been conducted in the area of protein lyophilization technology, and instability/stabilization during lyophilization and long-term storage. Many critical issues have been identified. To have an up-to-date perspective of the lyophilization process and more importantly, its application in formulating solid protein pharmaceuticals, this article reviews the recent investigations and achievements in these exciting areas, especially in the past 10 years. Four interrelated topics are discussed: lyophilization and its denaturation stresses, cryo- and lyo-protection of proteins by excipients, design of a robust lyophilization cycle, and with emphasis, instability, stabilization, and formulation of solid protein pharmaceuticals." @default.
- W2059564760 created "2016-06-24" @default.
- W2059564760 creator A5046597133 @default.
- W2059564760 date "2000-08-01" @default.
- W2059564760 modified "2023-10-11" @default.
- W2059564760 title "Lyophilization and development of solid protein pharmaceuticals" @default.
- W2059564760 cites W112580190 @default.
- W2059564760 cites W113354497 @default.
- W2059564760 cites W1276324155 @default.
- W2059564760 cites W130874531 @default.
- W2059564760 cites W134813434 @default.
- W2059564760 cites W13502199 @default.
- W2059564760 cites W141573972 @default.
- W2059564760 cites W1489640652 @default.
- W2059564760 cites W149157912 @default.
- W2059564760 cites W1493124133 @default.
- W2059564760 cites W1494681965 @default.
- W2059564760 cites W1496677456 @default.
- W2059564760 cites W1500111277 @default.
- W2059564760 cites W1508836098 @default.
- W2059564760 cites W1511036913 @default.
- W2059564760 cites W1511344763 @default.
- W2059564760 cites W1512228649 @default.
- W2059564760 cites W1517145530 @default.
- W2059564760 cites W1524122182 @default.
- W2059564760 cites W1526014545 @default.
- W2059564760 cites W1527234172 @default.
- W2059564760 cites W1539001309 @default.
- W2059564760 cites W1541736117 @default.
- W2059564760 cites W15436629 @default.
- W2059564760 cites W1550824762 @default.
- W2059564760 cites W1558381338 @default.
- W2059564760 cites W1558454853 @default.
- W2059564760 cites W1564900557 @default.
- W2059564760 cites W1569329587 @default.
- W2059564760 cites W1571473177 @default.
- W2059564760 cites W1576271719 @default.
- W2059564760 cites W1578802177 @default.
- W2059564760 cites W1582009577 @default.
- W2059564760 cites W1587621554 @default.
- W2059564760 cites W1597762671 @default.
- W2059564760 cites W1600942466 @default.
- W2059564760 cites W1602974455 @default.
- W2059564760 cites W1700796997 @default.
- W2059564760 cites W171395474 @default.
- W2059564760 cites W177408800 @default.
- W2059564760 cites W1830292764 @default.
- W2059564760 cites W1958799540 @default.
- W2059564760 cites W1964198706 @default.
- W2059564760 cites W1964832063 @default.
- W2059564760 cites W1968118833 @default.
- W2059564760 cites W1969000796 @default.
- W2059564760 cites W1972646050 @default.
- W2059564760 cites W1973204201 @default.
- W2059564760 cites W1976339839 @default.
- W2059564760 cites W1977996370 @default.
- W2059564760 cites W1979657652 @default.
- W2059564760 cites W1979739531 @default.
- W2059564760 cites W1980480845 @default.
- W2059564760 cites W1981000246 @default.
- W2059564760 cites W1981914844 @default.
- W2059564760 cites W1983451990 @default.
- W2059564760 cites W1984527471 @default.
- W2059564760 cites W1984655166 @default.
- W2059564760 cites W1985064820 @default.
- W2059564760 cites W1985706410 @default.
- W2059564760 cites W1986397390 @default.
- W2059564760 cites W1986673901 @default.
- W2059564760 cites W1986909585 @default.
- W2059564760 cites W1987690443 @default.
- W2059564760 cites W1988194663 @default.
- W2059564760 cites W1989492434 @default.
- W2059564760 cites W199106019 @default.
- W2059564760 cites W1991083965 @default.
- W2059564760 cites W1992106121 @default.
- W2059564760 cites W1992499929 @default.
- W2059564760 cites W1993533589 @default.
- W2059564760 cites W1994477016 @default.
- W2059564760 cites W1994799586 @default.
- W2059564760 cites W1995826438 @default.
- W2059564760 cites W1996659811 @default.
- W2059564760 cites W1996718452 @default.
- W2059564760 cites W1996784994 @default.
- W2059564760 cites W1997294622 @default.
- W2059564760 cites W1997772494 @default.
- W2059564760 cites W1998061050 @default.
- W2059564760 cites W1999937465 @default.
- W2059564760 cites W2001777220 @default.
- W2059564760 cites W2005063979 @default.
- W2059564760 cites W2005335136 @default.
- W2059564760 cites W2007679687 @default.
- W2059564760 cites W2007897007 @default.
- W2059564760 cites W2010050877 @default.
- W2059564760 cites W2010202516 @default.
- W2059564760 cites W2013287648 @default.
- W2059564760 cites W2013499814 @default.
- W2059564760 cites W2014163452 @default.
- W2059564760 cites W2015976014 @default.