FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059565914> ?p ?o ?g. }

• W2059565914 endingPage "177" @default.
• W2059565914 startingPage "177" @default.
• W2059565914 abstract "Cisplatin is a widely used chemotherapeutic agent in the treatment of cancers in clinic; but it often induces adverse effects on ovarian functions such as reduced fertility and premature menopause. Mesna could attenuate the cisplatin-induced ovarian damages; however, the underlying mechanism is still unknown. This study aimed to figure out the underlying mechanism of the protection of mesna for ovaries against cisplatin therapy in cancers.We performed female adult Sprague-Dawley rats into normal saline control (NS), low-dose cisplatin (CL), high-dose cisplatin (CH), CL plus mesna (CL+M), and CH plus mesna (CH+M) groups and detected anti-Müllerian hormone (AMH)-positive follicle, oxidative stress status and anti-oxidative capability in ovaries.AMH-positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesna was co-administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, but the anti-oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatin groups when compared with NS group. In contrast, after co-administration of cisplatin with mesna, MDA was significantly decreased whereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti-tumor property of cisplatin in HePG2 cell lines.Cisplatin damages the granulosa cells by oxidative stress to deplete the ovarian reserve and mesna could protect ovarian reserve through anti-oxidation. These results might highlight the mechanism of the protection of mesna for ovarian reserve and open an avenue for the application of mesna as a protective additive in cisplatin chemotherapy in clinical practise." @default.
• W2059565914 created "2016-06-24" @default.
• W2059565914 creator A5032269876 @default.
• W2059565914 creator A5040063776 @default.
• W2059565914 creator A5050670610 @default.
• W2059565914 creator A5059248751 @default.
• W2059565914 creator A5066345375 @default.
• W2059565914 creator A5074566396 @default.
• W2059565914 creator A5074777143 @default.
• W2059565914 date "2013-01-01" @default.
• W2059565914 modified "2023-09-27" @default.
• W2059565914 title "The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats" @default.
• W2059565914 cites W1927553784 @default.
• W2059565914 cites W1965788245 @default.
• W2059565914 cites W1965988269 @default.
• W2059565914 cites W1978928320 @default.
• W2059565914 cites W1986509767 @default.
• W2059565914 cites W1989583133 @default.
• W2059565914 cites W1993017912 @default.
• W2059565914 cites W2012323351 @default.
• W2059565914 cites W2014064608 @default.
• W2059565914 cites W2018520574 @default.
• W2059565914 cites W2023773512 @default.
• W2059565914 cites W2024375371 @default.
• W2059565914 cites W2025940858 @default.
• W2059565914 cites W2030825809 @default.
• W2059565914 cites W2033779225 @default.
• W2059565914 cites W2048123256 @default.
• W2059565914 cites W2052544801 @default.
• W2059565914 cites W2056803094 @default.
• W2059565914 cites W2065261267 @default.
• W2059565914 cites W2078567889 @default.
• W2059565914 cites W2090225356 @default.
• W2059565914 cites W2091926106 @default.
• W2059565914 cites W2117319789 @default.
• W2059565914 cites W2117631891 @default.
• W2059565914 cites W2119983127 @default.
• W2059565914 cites W2133523248 @default.
• W2059565914 cites W2143608188 @default.
• W2059565914 cites W2149170067 @default.
• W2059565914 cites W2157596954 @default.
• W2059565914 cites W2160329305 @default.
• W2059565914 cites W2161407968 @default.
• W2059565914 cites W2166881613 @default.
• W2059565914 cites W2168491045 @default.
• W2059565914 cites W2170505179 @default.
• W2059565914 doi "https://doi.org/10.3802/jgo.2013.24.2.177" @default.
• W2059565914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3644695" @default.
• W2059565914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23653836" @default.
• W2059565914 hasPublicationYear "2013" @default.
• W2059565914 type Work @default.
• W2059565914 sameAs 2059565914 @default.
• W2059565914 citedByCount "44" @default.
• W2059565914 countsByYear W20595659142013 @default.
• W2059565914 countsByYear W20595659142014 @default.
• W2059565914 countsByYear W20595659142015 @default.
• W2059565914 countsByYear W20595659142016 @default.
• W2059565914 countsByYear W20595659142017 @default.
• W2059565914 countsByYear W20595659142018 @default.
• W2059565914 countsByYear W20595659142019 @default.
• W2059565914 countsByYear W20595659142020 @default.
• W2059565914 countsByYear W20595659142021 @default.
• W2059565914 countsByYear W20595659142022 @default.
• W2059565914 countsByYear W20595659142023 @default.
• W2059565914 crossrefType "journal-article" @default.
• W2059565914 hasAuthorship W2059565914A5032269876 @default.
• W2059565914 hasAuthorship W2059565914A5040063776 @default.
• W2059565914 hasAuthorship W2059565914A5050670610 @default.
• W2059565914 hasAuthorship W2059565914A5059248751 @default.
• W2059565914 hasAuthorship W2059565914A5066345375 @default.
• W2059565914 hasAuthorship W2059565914A5074566396 @default.
• W2059565914 hasAuthorship W2059565914A5074777143 @default.
• W2059565914 hasBestOaLocation W20595659141 @default.
• W2059565914 hasConcept C126189478 @default.
• W2059565914 hasConcept C126322002 @default.
• W2059565914 hasConcept C134018914 @default.
• W2059565914 hasConcept C181199279 @default.
• W2059565914 hasConcept C185592680 @default.
• W2059565914 hasConcept C2776151105 @default.
• W2059565914 hasConcept C2776694085 @default.
• W2059565914 hasConcept C2777506904 @default.
• W2059565914 hasConcept C2778239845 @default.
• W2059565914 hasConcept C2780091579 @default.
• W2059565914 hasConcept C2780376820 @default.
• W2059565914 hasConcept C538909803 @default.
• W2059565914 hasConcept C55493867 @default.
• W2059565914 hasConcept C71924100 @default.
• W2059565914 hasConcept C98274493 @default.
• W2059565914 hasConceptScore W2059565914C126189478 @default.
• W2059565914 hasConceptScore W2059565914C126322002 @default.
• W2059565914 hasConceptScore W2059565914C134018914 @default.
• W2059565914 hasConceptScore W2059565914C181199279 @default.
• W2059565914 hasConceptScore W2059565914C185592680 @default.
• W2059565914 hasConceptScore W2059565914C2776151105 @default.
• W2059565914 hasConceptScore W2059565914C2776694085 @default.
• W2059565914 hasConceptScore W2059565914C2777506904 @default.
• W2059565914 hasConceptScore W2059565914C2778239845 @default.
• W2059565914 hasConceptScore W2059565914C2780091579 @default.

• next