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- W2059568081 abstract "The zinc finger proteins containing the Kruppel-associated box domain (KRAB) constitute the largest single family of transcriptional regulators in mammals. Many genes encoding members of this family are arranged in clusters. KRAB-containing proteins are characterized by the presence of 4 and over 30 C2H2 zinc-finger motifs and a KRAB domain near the amino terminus of the protein. KRAB domain behaving as a protein-protein interaction domain could bind to corepressor proteins and/or transcription factors, and that the KRAB-containing proteins could act as a repressor or corepressor and play a key role in transcriptional repression. Members of the family are involved in embryonic development, cell differentiation, cell proliferation, apoptosis, neoplastic transformation and cell cycle regulation." @default.
- W2059568081 created "2016-06-24" @default.
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- W2059568081 date "2006-01-01" @default.
- W2059568081 modified "2023-09-25" @default.
- W2059568081 title "Progress in the Study of KRAB Zinc Finger Protein" @default.
- W2059568081 doi "https://doi.org/10.1360/yc-006-1451" @default.
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