FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059574458> ?p ?o ?g. }

• W2059574458 endingPage "1574" @default.
• W2059574458 startingPage "1565" @default.
• W2059574458 abstract "Abstract The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) such as gefitinib and erlotinib have been widely used in treating patients with advanced non‐small cell lung cancer (NSCLC). However, acquired resistance to EGFR TKI almost occurs in every patient eventually. To identify its potential mechanism, we established a human NSCLC cell line PC9/AB2 which was 576‐fold decrease in gefitinib sensitivity compared with its parental PC9 cell lines. No EGFR‐T790M mutation or abnormal expression of c‐Met protein was found in PC9/AB2 cells. Over‐expression of integrin β1 was found, accompanied with increase of the cells' adhesion and migration. To further confirm the role of integrin β1 in gefitinib acquired resistance, we transferred its siRNA‐expressing plasmid and its whole cDNA expressing plasmid into PC9/AB2 and into PC9 cells, respectively. The sensitivity of NSCLC cells to gefitinib was negatively correlated with integrin β1 expression levels. All these data suggest that up‐regulation of integrin β1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2. J. Cell. Biochem. 111: 1565–1574, 2010. © 2010 Wiley‐Liss, Inc." @default.
• W2059574458 created "2016-06-24" @default.
• W2059574458 creator A5000432967 @default.
• W2059574458 creator A5024628268 @default.
• W2059574458 creator A5052763500 @default.
• W2059574458 creator A5074233771 @default.
• W2059574458 date "2010-11-29" @default.
• W2059574458 modified "2023-10-10" @default.
• W2059574458 title "Integrin beta1 over-expression associates with resistance to tyrosine kinase inhibitor gefitinib in non-small cell lung cancer" @default.
• W2059574458 cites W1580361048 @default.
• W2059574458 cites W1967394241 @default.
• W2059574458 cites W1989205333 @default.
• W2059574458 cites W1994567819 @default.
• W2059574458 cites W1998971866 @default.
• W2059574458 cites W2001829888 @default.
• W2059574458 cites W2002937040 @default.
• W2059574458 cites W2003984225 @default.
• W2059574458 cites W2004269633 @default.
• W2059574458 cites W2014187999 @default.
• W2059574458 cites W2037816726 @default.
• W2059574458 cites W2051120695 @default.
• W2059574458 cites W2068244265 @default.
• W2059574458 cites W2069312070 @default.
• W2059574458 cites W2070241543 @default.
• W2059574458 cites W2075264134 @default.
• W2059574458 cites W2080233238 @default.
• W2059574458 cites W2093613683 @default.
• W2059574458 cites W2093922887 @default.
• W2059574458 cites W2111109297 @default.
• W2059574458 cites W2115296606 @default.
• W2059574458 cites W2118135682 @default.
• W2059574458 cites W2120718661 @default.
• W2059574458 cites W2135550035 @default.
• W2059574458 cites W2136040107 @default.
• W2059574458 cites W2146404049 @default.
• W2059574458 cites W2161821474 @default.
• W2059574458 cites W2162799012 @default.
• W2059574458 cites W2168841302 @default.
• W2059574458 cites W2169816570 @default.
• W2059574458 cites W2340521092 @default.
• W2059574458 cites W2346637078 @default.
• W2059574458 cites W4231599003 @default.
• W2059574458 doi "https://doi.org/10.1002/jcb.22888" @default.
• W2059574458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21053345" @default.
• W2059574458 hasPublicationYear "2010" @default.
• W2059574458 type Work @default.
• W2059574458 sameAs 2059574458 @default.
• W2059574458 citedByCount "61" @default.
• W2059574458 countsByYear W20595744582012 @default.
• W2059574458 countsByYear W20595744582013 @default.
• W2059574458 countsByYear W20595744582014 @default.
• W2059574458 countsByYear W20595744582015 @default.
• W2059574458 countsByYear W20595744582016 @default.
• W2059574458 countsByYear W20595744582017 @default.
• W2059574458 countsByYear W20595744582018 @default.
• W2059574458 countsByYear W20595744582019 @default.
• W2059574458 countsByYear W20595744582020 @default.
• W2059574458 countsByYear W20595744582021 @default.
• W2059574458 crossrefType "journal-article" @default.
• W2059574458 hasAuthorship W2059574458A5000432967 @default.
• W2059574458 hasAuthorship W2059574458A5024628268 @default.
• W2059574458 hasAuthorship W2059574458A5052763500 @default.
• W2059574458 hasAuthorship W2059574458A5074233771 @default.
• W2059574458 hasConcept C121608353 @default.
• W2059574458 hasConcept C126322002 @default.
• W2059574458 hasConcept C1491633281 @default.
• W2059574458 hasConcept C195687474 @default.
• W2059574458 hasConcept C2776256026 @default.
• W2059574458 hasConcept C2777930144 @default.
• W2059574458 hasConcept C2778087573 @default.
• W2059574458 hasConcept C2779438470 @default.
• W2059574458 hasConcept C2780580887 @default.
• W2059574458 hasConcept C42362537 @default.
• W2059574458 hasConcept C502942594 @default.
• W2059574458 hasConcept C54355233 @default.
• W2059574458 hasConcept C62478195 @default.
• W2059574458 hasConcept C71924100 @default.
• W2059574458 hasConcept C86803240 @default.
• W2059574458 hasConcept C95444343 @default.
• W2059574458 hasConceptScore W2059574458C121608353 @default.
• W2059574458 hasConceptScore W2059574458C126322002 @default.
• W2059574458 hasConceptScore W2059574458C1491633281 @default.
• W2059574458 hasConceptScore W2059574458C195687474 @default.
• W2059574458 hasConceptScore W2059574458C2776256026 @default.
• W2059574458 hasConceptScore W2059574458C2777930144 @default.
• W2059574458 hasConceptScore W2059574458C2778087573 @default.
• W2059574458 hasConceptScore W2059574458C2779438470 @default.
• W2059574458 hasConceptScore W2059574458C2780580887 @default.
• W2059574458 hasConceptScore W2059574458C42362537 @default.
• W2059574458 hasConceptScore W2059574458C502942594 @default.
• W2059574458 hasConceptScore W2059574458C54355233 @default.
• W2059574458 hasConceptScore W2059574458C62478195 @default.
• W2059574458 hasConceptScore W2059574458C71924100 @default.
• W2059574458 hasConceptScore W2059574458C86803240 @default.
• W2059574458 hasConceptScore W2059574458C95444343 @default.
• W2059574458 hasIssue "6" @default.
• W2059574458 hasLocation W20595744581 @default.
• W2059574458 hasLocation W20595744582 @default.

• next