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- W2059576897 abstract "Objectives To investigate the frequency of azoospermia factor (AZF) deletions in Dutch patients with testicular germ cell tumors (TGCTs). Reduced fertility is associated with TGCTs and reduced fertility and TGCTs might share genetic risk factors according to the testicular dysgenesis hypothesis. Up to 8% of infertility and reduced fertility in the general male population can be explained by the presence of constitutional deletions of part of the long arm of the Y chromosome (Yq11), referred to as the AZF region. Methods In 112 patients with TGCT, screening for constitutional deletions in the AZF region was performed by multiplex polymerase chain reaction analysis in DNA extracted from peripheral blood lymphocytes. A set of 24 primer pairs, of which 20 primer pairs are homologous to previously identified and mapped sequenced tag sites within the AZF region were used. Results No deletions in the Yq11 region were detected in any of the 112 patients. Conclusions Large Y chromosome microdeletions in the AZF region are not a major contributor to the development of TGCT and TGCT-associated reduced fertility." @default.
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- W2059576897 date "2005-01-01" @default.
- W2059576897 modified "2023-09-27" @default.
- W2059576897 title "Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors" @default.
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- W2059576897 doi "https://doi.org/10.1016/j.urology.2004.09.022" @default.
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