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- W2059587869 abstract "Fluticasone propionate reduces the frequency and severity of the episodes of exacerbation of chronic obstructive pulmonary disease (COPD). <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> are frequently isolated in these episodes. Both express phosphorylcholine, an epitope that mediates their interaction with airway epithelial cells <i>via</i> the platelet-activating factor receptor (PAFR). The present work studies the effects of fluticasone propionate on the expression of PAFR on human airway epithelial cells, the invasion of these cells by <i>S. pneumoniae</i> and <i>H. influenzae</i>, and the course of pneumococcal infection <i>in vivo</i>. The following were used in the experiments: <i>S. pneumoniae</i> and <i>H. influenzae</i> isolated from patients with COPD, cell cultures of type II pneumocytes and bronchoepithelial cells, and a mouse model of lung infection. Fluticasone propionate was found to reduce PAFR expression on the surface of the two cells types studied. All <i>S. pneumoniae</i> and <i>H. influenzae</i> isolates expressed phosphorylcholine. Treatment of both cells lines with fluticasone propionate reduced invasion of both microorganisms and reduced the bacterial load of mice infected with <i>S. pneumoniae</i>. Fluticasone propionate reduces the invasion of airway epithelial cells by <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> through its effect on platelet-activating factor receptor. These results may help explain the beneficial effects of fluticasone propionate on chronic obstructive pulmonary disease exacerbations." @default.
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- W2059587869 date "2008-11-01" @default.
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- W2059587869 title "Fluticasone propionate reduces bacterial airway epithelial invasion" @default.
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- W2059587869 doi "https://doi.org/10.1183/09031936.00020608" @default.
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