Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059587912> ?p ?o ?g. }
- W2059587912 endingPage "772" @default.
- W2059587912 startingPage "761" @default.
- W2059587912 abstract "The study and characterization of unliganded openings is of central significance for the elucidation of gating mechanisms for allosteric ligand-gated ion channels. Unliganded openings have been reported for many channel types, but their low open probability can make it difficult to study their kinetics in detail. Because the large conductance calcium-activated potassium channel mSlo is sensitive to both intracellular calcium and to membrane potential, we have been able to obtain stable unliganded single-channel recordings of mSlo with relatively high opening probability. We have found that the single-channel gating behavior of mSlo is complex, with multiple open and closed states, even when no ligand is present. Our results rule out a Monod–Wyman–Changeux allosteric mechanism with a central voltage-dependent concerted step, and they support the existence of quaternary states with less than the full number of voltage sensors activated, as has been suggested by previous work involving measurements of gating currents." @default.
- W2059587912 created "2016-06-24" @default.
- W2059587912 creator A5051410023 @default.
- W2059587912 creator A5068815023 @default.
- W2059587912 date "2000-02-01" @default.
- W2059587912 modified "2023-10-15" @default.
- W2059587912 title "Complex Voltage-Dependent Behavior of Single Unliganded Calcium-Sensitive Potassium Channels" @default.
- W2059587912 cites W1641032390 @default.
- W2059587912 cites W1642445429 @default.
- W2059587912 cites W1965021455 @default.
- W2059587912 cites W1968134283 @default.
- W2059587912 cites W1972994417 @default.
- W2059587912 cites W1974695854 @default.
- W2059587912 cites W1977810278 @default.
- W2059587912 cites W1979165244 @default.
- W2059587912 cites W1984104453 @default.
- W2059587912 cites W1987493270 @default.
- W2059587912 cites W1991093565 @default.
- W2059587912 cites W1993579898 @default.
- W2059587912 cites W1998093640 @default.
- W2059587912 cites W2001347775 @default.
- W2059587912 cites W2003234320 @default.
- W2059587912 cites W2005392755 @default.
- W2059587912 cites W2012605007 @default.
- W2059587912 cites W2020895826 @default.
- W2059587912 cites W2027991308 @default.
- W2059587912 cites W2036861927 @default.
- W2059587912 cites W2051646037 @default.
- W2059587912 cites W2052037844 @default.
- W2059587912 cites W2063211822 @default.
- W2059587912 cites W2067967075 @default.
- W2059587912 cites W2072977328 @default.
- W2059587912 cites W2075917120 @default.
- W2059587912 cites W2083517299 @default.
- W2059587912 cites W2084386763 @default.
- W2059587912 cites W2089103245 @default.
- W2059587912 cites W2094717658 @default.
- W2059587912 cites W2095952083 @default.
- W2059587912 cites W2101966660 @default.
- W2059587912 cites W2108953775 @default.
- W2059587912 cites W2109196366 @default.
- W2059587912 cites W2129844520 @default.
- W2059587912 cites W2136166415 @default.
- W2059587912 cites W2138489954 @default.
- W2059587912 cites W2147323143 @default.
- W2059587912 cites W2155885957 @default.
- W2059587912 cites W2159841012 @default.
- W2059587912 cites W4301028247 @default.
- W2059587912 cites W51410544 @default.
- W2059587912 doi "https://doi.org/10.1016/s0006-3495(00)76634-3" @default.
- W2059587912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1300679" @default.
- W2059587912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10653789" @default.
- W2059587912 hasPublicationYear "2000" @default.
- W2059587912 type Work @default.
- W2059587912 sameAs 2059587912 @default.
- W2059587912 citedByCount "39" @default.
- W2059587912 countsByYear W20595879122012 @default.
- W2059587912 countsByYear W20595879122014 @default.
- W2059587912 countsByYear W20595879122015 @default.
- W2059587912 countsByYear W20595879122017 @default.
- W2059587912 countsByYear W20595879122021 @default.
- W2059587912 crossrefType "journal-article" @default.
- W2059587912 hasAuthorship W2059587912A5051410023 @default.
- W2059587912 hasAuthorship W2059587912A5068815023 @default.
- W2059587912 hasBestOaLocation W20595879121 @default.
- W2059587912 hasConcept C116569031 @default.
- W2059587912 hasConcept C121332964 @default.
- W2059587912 hasConcept C121932024 @default.
- W2059587912 hasConcept C12554922 @default.
- W2059587912 hasConcept C149614440 @default.
- W2059587912 hasConcept C166342909 @default.
- W2059587912 hasConcept C170493617 @default.
- W2059587912 hasConcept C178790620 @default.
- W2059587912 hasConcept C181911157 @default.
- W2059587912 hasConcept C185592680 @default.
- W2059587912 hasConcept C194544171 @default.
- W2059587912 hasConcept C26873012 @default.
- W2059587912 hasConcept C50254741 @default.
- W2059587912 hasConcept C517785266 @default.
- W2059587912 hasConcept C519063684 @default.
- W2059587912 hasConcept C55493867 @default.
- W2059587912 hasConcept C83743174 @default.
- W2059587912 hasConcept C86803240 @default.
- W2059587912 hasConceptScore W2059587912C116569031 @default.
- W2059587912 hasConceptScore W2059587912C121332964 @default.
- W2059587912 hasConceptScore W2059587912C121932024 @default.
- W2059587912 hasConceptScore W2059587912C12554922 @default.
- W2059587912 hasConceptScore W2059587912C149614440 @default.
- W2059587912 hasConceptScore W2059587912C166342909 @default.
- W2059587912 hasConceptScore W2059587912C170493617 @default.
- W2059587912 hasConceptScore W2059587912C178790620 @default.
- W2059587912 hasConceptScore W2059587912C181911157 @default.
- W2059587912 hasConceptScore W2059587912C185592680 @default.
- W2059587912 hasConceptScore W2059587912C194544171 @default.
- W2059587912 hasConceptScore W2059587912C26873012 @default.
- W2059587912 hasConceptScore W2059587912C50254741 @default.
- W2059587912 hasConceptScore W2059587912C517785266 @default.
- W2059587912 hasConceptScore W2059587912C519063684 @default.