FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059592506> ?p ?o ?g. }

• W2059592506 abstract "Genes that regulate stem cell function are suspected to exert adverse effects on prognosis in malignancy. However, diverse cancer stem cell signatures are difficult for physicians to interpret and apply clinically. To connect the transcriptome and stem cell biology, with potential clinical applications, we propose a novel computational “gene-to-function, snapshot-to-dynamics, and biology-to-clinic” framework to uncover core functional gene-sets signatures. This framework incorporates three function-centric gene-set analysis strategies: a meta-analysis of both microarray and RNA-seq data, novel dynamic network mechanism (DNM) identification, and a personalized prognostic indicator analysis. This work uses complex disease acute myeloid leukemia (AML) as a research platform. We introduced an adjustable “soft threshold” to a functional gene-set algorithm and found that two different analysis methods identified distinct gene-set signatures from the same samples. We identified a 30-gene cluster that characterizes leukemic stem cell (LSC)-depleted cells and a 25-gene cluster that characterizes LSC-enriched cells in parallel; both mark favorable-prognosis in AML. Genes within each signature significantly share common biological processes and/or molecular functions (empirical p = 6e-5 and 0.03 respectively). The 25-gene signature reflects the abnormal development of stem cells in AML, such as AURKA over-expression. We subsequently determined that the clinical relevance of both signatures is independent of known clinical risk classifications in 214 patients with cytogenetically normal AML. We successfully validated the prognosis of both signatures in two independent cohorts of 91 and 242 patients respectively (log-rank p < 0.0015 and 0.05; empirical p < 0.015 and 0.08). The proposed algorithms and computational framework will harness systems biology research because they efficiently translate gene-sets (rather than single genes) into biological discoveries about AML and other complex diseases." @default.
• W2059592506 created "2016-06-24" @default.
• W2059592506 creator A5012283696 @default.
• W2059592506 creator A5015950934 @default.
• W2059592506 creator A5020794469 @default.
• W2059592506 creator A5029357370 @default.
• W2059592506 creator A5032046795 @default.
• W2059592506 creator A5033732336 @default.
• W2059592506 creator A5057326412 @default.
• W2059592506 creator A5074288964 @default.
• W2059592506 creator A5075314060 @default.
• W2059592506 creator A5079231875 @default.
• W2059592506 date "2015-03-24" @default.
• W2059592506 modified "2023-10-16" @default.
• W2059592506 title "Systematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia" @default.
• W2059592506 cites W1255676896 @default.
• W2059592506 cites W1597454894 @default.
• W2059592506 cites W1694703176 @default.
• W2059592506 cites W1965113891 @default.
• W2059592506 cites W1967358345 @default.
• W2059592506 cites W1976900233 @default.
• W2059592506 cites W1977977741 @default.
• W2059592506 cites W1983641075 @default.
• W2059592506 cites W1983973807 @default.
• W2059592506 cites W1989532420 @default.
• W2059592506 cites W2000996935 @default.
• W2059592506 cites W2002213310 @default.
• W2059592506 cites W2010457001 @default.
• W2059592506 cites W2011417152 @default.
• W2059592506 cites W2019523681 @default.
• W2059592506 cites W2022335352 @default.
• W2059592506 cites W2022397091 @default.
• W2059592506 cites W2026970599 @default.
• W2059592506 cites W2035471593 @default.
• W2059592506 cites W2039365544 @default.
• W2059592506 cites W2047461198 @default.
• W2059592506 cites W2060749612 @default.
• W2059592506 cites W2062317197 @default.
• W2059592506 cites W2063544405 @default.
• W2059592506 cites W2064236642 @default.
• W2059592506 cites W2065956458 @default.
• W2059592506 cites W2072245877 @default.
• W2059592506 cites W2076922627 @default.
• W2059592506 cites W2084533385 @default.
• W2059592506 cites W2090982381 @default.
• W2059592506 cites W2092599098 @default.
• W2059592506 cites W2093638163 @default.
• W2059592506 cites W2100714130 @default.
• W2059592506 cites W2100980426 @default.
• W2059592506 cites W2107851174 @default.
• W2059592506 cites W2110065044 @default.
• W2059592506 cites W2117096174 @default.
• W2059592506 cites W2126124351 @default.
• W2059592506 cites W2127053639 @default.
• W2059592506 cites W2130410032 @default.
• W2059592506 cites W2133650451 @default.
• W2059592506 cites W2136294817 @default.
• W2059592506 cites W2141849512 @default.
• W2059592506 cites W2146506071 @default.
• W2059592506 cites W2156911730 @default.
• W2059592506 cites W2159707944 @default.
• W2059592506 cites W2164594706 @default.
• W2059592506 cites W2170219300 @default.
• W2059592506 cites W2171070506 @default.
• W2059592506 cites W2208491121 @default.
• W2059592506 cites W2406871555 @default.
• W2059592506 doi "https://doi.org/10.1186/s12859-015-0510-7" @default.
• W2059592506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4376348" @default.
• W2059592506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25887548" @default.
• W2059592506 hasPublicationYear "2015" @default.
• W2059592506 type Work @default.
• W2059592506 sameAs 2059592506 @default.
• W2059592506 citedByCount "12" @default.
• W2059592506 countsByYear W20595925062015 @default.
• W2059592506 countsByYear W20595925062016 @default.
• W2059592506 countsByYear W20595925062018 @default.
• W2059592506 countsByYear W20595925062019 @default.
• W2059592506 countsByYear W20595925062020 @default.
• W2059592506 countsByYear W20595925062022 @default.
• W2059592506 crossrefType "journal-article" @default.
• W2059592506 hasAuthorship W2059592506A5012283696 @default.
• W2059592506 hasAuthorship W2059592506A5015950934 @default.
• W2059592506 hasAuthorship W2059592506A5020794469 @default.
• W2059592506 hasAuthorship W2059592506A5029357370 @default.
• W2059592506 hasAuthorship W2059592506A5032046795 @default.
• W2059592506 hasAuthorship W2059592506A5033732336 @default.
• W2059592506 hasAuthorship W2059592506A5057326412 @default.
• W2059592506 hasAuthorship W2059592506A5074288964 @default.
• W2059592506 hasAuthorship W2059592506A5075314060 @default.
• W2059592506 hasAuthorship W2059592506A5079231875 @default.
• W2059592506 hasBestOaLocation W20595925061 @default.
• W2059592506 hasConcept C104317684 @default.
• W2059592506 hasConcept C150194340 @default.
• W2059592506 hasConcept C162317418 @default.
• W2059592506 hasConcept C18431079 @default.
• W2059592506 hasConcept C2778461978 @default.
• W2059592506 hasConcept C2778729363 @default.
• W2059592506 hasConcept C2779733811 @default.
• W2059592506 hasConcept C28328180 @default.
• W2059592506 hasConcept C502942594 @default.

• next