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- W2059593644 abstract "<h2>Abstract</h2> The effect of β-adrenergic blockade on regional left ventricular wall motion abnormalities was studied in 11 patients with coronary artery disease and silent myocardial ischemia during exercise testing. Four patients were asymptomatic; 7 were asymptomatic after a myocardial infarction. Left ventricular wall motion abnormalities were characterized by reduced regional ejection fraction (EF) during exercise as determined by gated left anterior oblique images of the cardiac blood pool. In the 11 patients, 10 anteroseptal and 8 inferoposterior regions were subserved by stenotic coronary arteries. Before β blockade, regional EF decreased in 15 of 18 regions. After β blockade, this occurred in only 6 of 18 regions (p < 0.05); the other 12 regions showed no change or an actual increase in regional EF. Thus, β-adrenergic blockade effectively improved the reduction in exercise regional EF usually seen in patients with coronary artery disease with silent myocardial ischemia. One probable mechanism of action is a reduction in myocardial oxygen requirement at peak exercise." @default.
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- W2059593644 date "1986-05-01" @default.
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- W2059593644 title "Effect of beta blockade on silent regional left ventricular wall motion abnormalities" @default.
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- W2059593644 doi "https://doi.org/10.1016/0002-9149(86)90828-3" @default.
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