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• W2059594773 abstract "Abstract Aim We investigated the diagnostic performance of urinary kidney injury molecule‐1 ( KIM ‐1) and neutrophil gelatinase‐associated lipocalin ( NGAL ) for acute kidney injury ( AKI ) in 90 obstructive nephropathy patients. Methods Urine samples were obtained preoperatively and 4, 8, 12, 24, 48 and 72 h postoperatively, and urinary KIM ‐1 and NGAL contents were measured by enzyme linked immunosorbent assay and corrected against urine creatinine content. The receiver operating characteristic ( ROC ) curves were used to determine the area under the curve ( AUCs ) of urinary KIM ‐1 and NGAL for AKI . Results The baseline urinary KIM ‐1 contents were higher in AKI patients than non‐ AKI patients ( P < 0.01). Urinary NGAL contents were also higher in AKI patients than non‐ AKI patients ( P < 0.001). The area under the curve ( AUC ) of urinary KIM ‐1 was 0.900 ( P = 0.004) and at a cutoff of 338.26 pg/mg C r, the sensitivity was 90% and the specificity was 75%. The AUC of urinary NGAL was 0.900 ( P = 0.004) and at a cutoff of 261.76 ng/mg C r, the sensitivity was 90% and the specificity was 87.5%. The combined AUC of urinary KIM‐ 1 and NGAL was 0.938 ( P = 0.002) with a sensitivity of 90% and a specificity of 100%. Cox regression analysis revealed that urinary KIM ‐1content 72 h after operation correlated with the prognosis of AKI patients ( P = 0.009). When kidney viability was stratified by urinary KIM ‐1 content 72 h postoperatively, K aplan– M eier analysis showed that patients with a urinary content of KIM ‐1 < 138.20 pg/mg had a higher kidney viability rate than those with a urinary content of KIM ‐1 > 138.20 pg/mg. Conclusion Urinary KIM ‐1 and NGAL had a good accuracy for detecting AKI . KIM ‐1 72 h postoperatively can predict the renal outcome of obstructive nephropathy." @default.
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• W2059594773 date "2014-03-24" @default.
• W2059594773 modified "2023-10-09" @default.
• W2059594773 title "Diagnostic performance of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for acute kidney injury in an obstructive nephropathy patient" @default.
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• W2059594773 doi "https://doi.org/10.1111/nep.12173" @default.
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