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- W2059598864 abstract "The most effective countermeasure against a pandemic originating from a highly pathogenic avian influenza virus (HPAIV) is immunoprophylaxis of the human population. We present here a new approach for the development of a pandemic HPAIV live vaccine. Using reverse genetics, we replaced the polybasic hemagglutinin cleavage site of an H7N7 HPAIV with an elastase motif. This mutant was strictly elastase-dependent, grew equally well as the wild-type in cell culture and was attenuated in mice unlike the lethal wild-type. Immunization at 10(6)pfu dosage protected mice against disease and induced sterile immunity; vaccination with homosubtypic or heterosubtypic reassortants led to cross-protection. These observations demonstrate that a mutated hemagglutinin requiring elastase cleavage can serve as an attenuating component of a live vaccine against HPAIV." @default.
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- W2059598864 date "2008-02-01" @default.
- W2059598864 modified "2023-10-17" @default.
- W2059598864 title "The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine" @default.
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- W2059598864 doi "https://doi.org/10.1016/j.vaccine.2007.11.052" @default.
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