Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059599245> ?p ?o ?g. }
- W2059599245 endingPage "208" @default.
- W2059599245 startingPage "199" @default.
- W2059599245 abstract "The mechanism of the trichomonicidal activity of metronidazole and other 5-nitroimidazoles appears to depend on the ferredoxin-mediated reduction of their nitro group, with generation of a reactive metabolite or metabolites which interact with DNA leading to a subsequent inhibition of nucleic acid and protein synthesis. Redox cycling of these compounds under aerobic conditions appears to be a detoxification reaction by inhibiting net reduction of the drugs, thereby inhibiting their uptake. On the other hand, redox cycling of nitrofurans or other compounds with more positive reduction potential results in formation of high steady-state concentrations of oxygen-derived metabolites that might be of toxicological significance. It seems likely that reduced metabolites of nitroimidazoles (perhaps through covalent binding to tissue macromolecules and/or thiols depletion) are also involved in the nitroimidazoles' toxic effects to animal tissues and in their mutagenic and carcinogenic action." @default.
- W2059599245 created "2016-06-24" @default.
- W2059599245 creator A5000842323 @default.
- W2059599245 creator A5032324284 @default.
- W2059599245 date "1985-12-01" @default.
- W2059599245 modified "2023-10-11" @default.
- W2059599245 title "Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis." @default.
- W2059599245 cites W109118848 @default.
- W2059599245 cites W1479903 @default.
- W2059599245 cites W1481417992 @default.
- W2059599245 cites W1496775241 @default.
- W2059599245 cites W1507177543 @default.
- W2059599245 cites W1512276827 @default.
- W2059599245 cites W1523902471 @default.
- W2059599245 cites W1527170190 @default.
- W2059599245 cites W1576484112 @default.
- W2059599245 cites W1580909913 @default.
- W2059599245 cites W1586114810 @default.
- W2059599245 cites W1597357948 @default.
- W2059599245 cites W16843777 @default.
- W2059599245 cites W1887651321 @default.
- W2059599245 cites W1940436875 @default.
- W2059599245 cites W1965596803 @default.
- W2059599245 cites W1966146312 @default.
- W2059599245 cites W1967138380 @default.
- W2059599245 cites W1967502884 @default.
- W2059599245 cites W1973399917 @default.
- W2059599245 cites W1976311564 @default.
- W2059599245 cites W1981569736 @default.
- W2059599245 cites W1983743812 @default.
- W2059599245 cites W1984832811 @default.
- W2059599245 cites W1986234649 @default.
- W2059599245 cites W1990393030 @default.
- W2059599245 cites W1991921280 @default.
- W2059599245 cites W1994498894 @default.
- W2059599245 cites W2004312516 @default.
- W2059599245 cites W2004533923 @default.
- W2059599245 cites W2007707544 @default.
- W2059599245 cites W2009877488 @default.
- W2059599245 cites W2012673103 @default.
- W2059599245 cites W2014166067 @default.
- W2059599245 cites W2019423250 @default.
- W2059599245 cites W2019551056 @default.
- W2059599245 cites W2023183821 @default.
- W2059599245 cites W2028964978 @default.
- W2059599245 cites W2029669573 @default.
- W2059599245 cites W2029704116 @default.
- W2059599245 cites W2032164289 @default.
- W2059599245 cites W2032164977 @default.
- W2059599245 cites W2038729376 @default.
- W2059599245 cites W2043447478 @default.
- W2059599245 cites W2044635050 @default.
- W2059599245 cites W2044842036 @default.
- W2059599245 cites W2046369682 @default.
- W2059599245 cites W2051672692 @default.
- W2059599245 cites W2058992321 @default.
- W2059599245 cites W2061590657 @default.
- W2059599245 cites W2062916685 @default.
- W2059599245 cites W2066539751 @default.
- W2059599245 cites W2069877145 @default.
- W2059599245 cites W2080501796 @default.
- W2059599245 cites W2085766204 @default.
- W2059599245 cites W2091089879 @default.
- W2059599245 cites W2093375611 @default.
- W2059599245 cites W2095104953 @default.
- W2059599245 cites W2114708620 @default.
- W2059599245 cites W2127832091 @default.
- W2059599245 cites W2134705779 @default.
- W2059599245 cites W2140245137 @default.
- W2059599245 cites W2150440884 @default.
- W2059599245 cites W2156963748 @default.
- W2059599245 cites W2170359362 @default.
- W2059599245 cites W2256447349 @default.
- W2059599245 cites W2259761762 @default.
- W2059599245 cites W2265454289 @default.
- W2059599245 cites W2341210692 @default.
- W2059599245 cites W2411855757 @default.
- W2059599245 cites W2411959589 @default.
- W2059599245 cites W2413474458 @default.
- W2059599245 cites W2415983923 @default.
- W2059599245 cites W2417401997 @default.
- W2059599245 cites W2421242573 @default.
- W2059599245 cites W2491900015 @default.
- W2059599245 cites W2983771415 @default.
- W2059599245 cites W3119931 @default.
- W2059599245 cites W4301744801 @default.
- W2059599245 cites W977533169 @default.
- W2059599245 doi "https://doi.org/10.1289/ehp.8564199" @default.
- W2059599245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568619" @default.
- W2059599245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3830698" @default.
- W2059599245 hasPublicationYear "1985" @default.
- W2059599245 type Work @default.
- W2059599245 sameAs 2059599245 @default.
- W2059599245 citedByCount "108" @default.
- W2059599245 countsByYear W20595992452012 @default.
- W2059599245 countsByYear W20595992452013 @default.
- W2059599245 countsByYear W20595992452014 @default.
- W2059599245 countsByYear W20595992452015 @default.