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• W2059599324 abstract "The rapid accumulation of new knowledge on the genes, gene variations and genetic loci associated with both forms of inflammatory bowel disease (IBD), e.g. Crohn’s disease (CD) and ulcerative colitis (UC), is shedding new light on the immunopathogenic mechanisms underlying these conditions. After the initial report of the association of <i>NOD2</i> mutations with ileal CD, a large number of additional genetic variants and loci has been found to be associated with both CD and UC, CD alone and, quite recently, UC-associated variants have also emerged. Much of this progress is due to the use of methods such as genome-wide associations (GWA) based on large numbers of reasonably well-characterized patient groups. Among several others, some of the most pathophysiologically relevant associations reported so far are with gene variants related to innate immunity, autophagy, apoptosis, Th1 and Th17 responses, T cell activation, and immunosuppression. Some of these associations have lent further support to previously construed disease mechanisms or disclosed brand new mechanisms, like in the case of the autophagy pathway. While this much progress is obviously welcome, it also brings new challenges. These include the fact that all the gene mutations uncovered so far only account for a minority of all IBD cases, the variable distribution of gene mutations among worldwide IBD populations, and the still unknown effects of gene-gene and gene-environment interactions. Nevertheless, there is no question that genetic information will be quickly utilized not only for a better understanding of IBD pathogenesis, but it will also soon be incorporated into the armamentarium of better diagnostic and therapeutic tools." @default.
• W2059599324 created "2016-06-24" @default.
• W2059599324 creator A5043396915 @default.
• W2059599324 date "2009-01-01" @default.
• W2059599324 modified "2023-09-23" @default.
• W2059599324 title "Susceptibility Genes and Overall Pathogenesis of Inflammatory Bowel Disease: Where Do We Stand?" @default.
• W2059599324 cites W1487097573 @default.
• W2059599324 cites W1553717629 @default.
• W2059599324 cites W1642457845 @default.
• W2059599324 cites W1964909764 @default.
• W2059599324 cites W1967089274 @default.
• W2059599324 cites W1967376949 @default.
• W2059599324 cites W1968067289 @default.
• W2059599324 cites W1973823565 @default.
• W2059599324 cites W1977538419 @default.
• W2059599324 cites W1981568232 @default.
• W2059599324 cites W1981714996 @default.
• W2059599324 cites W1989303754 @default.
• W2059599324 cites W1990296143 @default.
• W2059599324 cites W1993458743 @default.
• W2059599324 cites W2001828968 @default.
• W2059599324 cites W2003099302 @default.
• W2059599324 cites W2010203932 @default.
• W2059599324 cites W2011197968 @default.
• W2059599324 cites W2015578131 @default.
• W2059599324 cites W2021706207 @default.
• W2059599324 cites W2030784582 @default.
• W2059599324 cites W2032385298 @default.
• W2059599324 cites W2033082339 @default.
• W2059599324 cites W2034132952 @default.
• W2059599324 cites W2042260827 @default.
• W2059599324 cites W2051505451 @default.
• W2059599324 cites W2053411326 @default.
• W2059599324 cites W2064858877 @default.
• W2059599324 cites W2066203385 @default.
• W2059599324 cites W2068322193 @default.
• W2059599324 cites W2069968649 @default.
• W2059599324 cites W2072147430 @default.
• W2059599324 cites W2073527744 @default.
• W2059599324 cites W2075453032 @default.
• W2059599324 cites W2075583035 @default.
• W2059599324 cites W2075739253 @default.
• W2059599324 cites W2078621117 @default.
• W2059599324 cites W2086607027 @default.
• W2059599324 cites W2088449391 @default.
• W2059599324 cites W2092160468 @default.
• W2059599324 cites W2093949724 @default.
• W2059599324 cites W2097050933 @default.
• W2059599324 cites W2097121808 @default.
• W2059599324 cites W2098662346 @default.
• W2059599324 cites W2100443415 @default.
• W2059599324 cites W2101881537 @default.
• W2059599324 cites W2102550380 @default.
• W2059599324 cites W2111900042 @default.
• W2059599324 cites W2114216755 @default.
• W2059599324 cites W2116552560 @default.
• W2059599324 cites W2118352951 @default.
• W2059599324 cites W2122031852 @default.
• W2059599324 cites W2123466824 @default.
• W2059599324 cites W2126874760 @default.
• W2059599324 cites W2128175802 @default.
• W2059599324 cites W2128791737 @default.
• W2059599324 cites W2129790158 @default.
• W2059599324 cites W2130241188 @default.
• W2059599324 cites W2131186249 @default.
• W2059599324 cites W2134783591 @default.
• W2059599324 cites W2135100507 @default.
• W2059599324 cites W2140541855 @default.
• W2059599324 cites W2143500139 @default.
• W2059599324 cites W2148936378 @default.
• W2059599324 cites W2149400414 @default.
• W2059599324 cites W2152748900 @default.
• W2059599324 cites W2153905079 @default.
• W2059599324 cites W2155033804 @default.
• W2059599324 cites W2157759877 @default.
• W2059599324 cites W2158507534 @default.
• W2059599324 cites W2158820172 @default.
• W2059599324 cites W2164788043 @default.
• W2059599324 cites W2165872127 @default.
• W2059599324 cites W2168647393 @default.
• W2059599324 cites W2169330513 @default.
• W2059599324 cites W2333959076 @default.
• W2059599324 cites W2545583725 @default.
• W2059599324 cites W7272284 @default.
• W2059599324 cites W2065591755 @default.
• W2059599324 cites W2116522000 @default.
• W2059599324 cites W2342942833 @default.
• W2059599324 doi "https://doi.org/10.1159/000228554" @default.
• W2059599324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786745" @default.
• W2059599324 hasPublicationYear "2009" @default.
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