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• W2059608909 abstract "Ex vivo monocyte cytokine responses (IL-1beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-exposed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-alpha and IL-1beta responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10, TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens." @default.
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• W2059608909 date "2006-02-01" @default.
• W2059608909 modified "2023-10-06" @default.
• W2059608909 title "Gastrointestinal nematode infection is associated with variation in innate immune responsiveness" @default.
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• W2059608909 doi "https://doi.org/10.1016/j.micinf.2005.07.025" @default.
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