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- W2059611140 abstract "Most of antisense oligonucleotides (ASOs) subjected to current clinical evaluation belong to phosphorothioate (PS) analogues. Although PS has great advantage in DNase resistance, it can induce nonspecific side-effects. Thus it is important to investigate the influence of ASOs with different PS contents. In this paper, we prepared the complex consisting of schizophyllan (SPG) and ASOs attached a dA40 tail with different PS contents to the 3′ end of the ODN, which is introduced to stabilize the complex with SPG. With increase of PS content in the dA40, its complexation ability with SPG was improved and the complex showed high thermal stability. The thermal stability of the fully phosphorothioated ASOs was obtained by only replacing 20% of the oxygen of the phosphodiester moiety. The ability of gene suppression between PS and phosphodiester for antisense sequences was almost the same, indicating that the antisense sequences need not to be PS backbone. These data may provide new insight for the interaction between β-1,3-glucan and DNA and help to deliver therapeutic ODNs." @default.
- W2059611140 created "2016-06-24" @default.
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- W2059611140 date "2010-12-01" @default.
- W2059611140 modified "2023-09-30" @default.
- W2059611140 title "β-1,3-Glucan/antisense oligonucleotide complex stabilized with phosphorothioation and its gene suppression" @default.
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- W2059611140 doi "https://doi.org/10.1016/j.bioorg.2010.07.001" @default.
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