Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059617408> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2059617408 endingPage "78" @default.
- W2059617408 startingPage "73" @default.
- W2059617408 abstract "The kinetics of formation (clot time; CT) as well as a mechanical parameter (breaking strength; BS) of fibrin were measured at various concentrations of fibrinogen. In a pure system and for a fixed level of thrombin, the CT-fibrinogen dependency was biphasic, reaching a minimum in the range 1-8 μM fibrinogen. A new parameter, [Fib]min, the minimal fibrinogen concentration required for phase change, was derived from this. The [Fib]min values of pure fibrinogen activated with thrombin, ranged between 0.15 and 0.25 μM fibrinogen. Single donor cryoprecipitate (cryo) had similar kinetics and [Fib]min value. A technique for measuring the innate breaking strength of fibrin, independently of its adhesive properties, is described. For pure fibrin activated with thrombin, the BS was a linear function of fibrinogen concentration, with numeric values for the slope of 0.84 g/μM and slopec, (with 2.5 mM Ca) of 2.26 g/μM, which transformed into a general description of the BS of fibrin and the fibrinogen level according to the equation: BS = μ [Fib]. The constants μ = 18.9 dyne/μM-cm2 and μc = 55.7 dyne/μM-cm2 reflect the innate strength of fibrin clot per cross-section area. Cryo fibrin exhibited a BS equivalent to its fibrinogen level in a pure system. Although scanning electron microscopy of pure and cryo fibrin formed at equivalent fibrinogen levels revealed significant ultrastructural disparity between the pure and cryo fibrin, the kinetics of formation and the mechanical parameters of both were comparable." @default.
- W2059617408 created "2016-06-24" @default.
- W2059617408 creator A5010924510 @default.
- W2059617408 creator A5063344555 @default.
- W2059617408 date "1993-02-01" @default.
- W2059617408 modified "2023-10-17" @default.
- W2059617408 title "Kinetic and mechanical parameters of pure and cryoprecipitate fibrin" @default.
- W2059617408 doi "https://doi.org/10.1097/00001721-199302000-00012" @default.
- W2059617408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8457656" @default.
- W2059617408 hasPublicationYear "1993" @default.
- W2059617408 type Work @default.
- W2059617408 sameAs 2059617408 @default.
- W2059617408 citedByCount "13" @default.
- W2059617408 countsByYear W20596174082018 @default.
- W2059617408 countsByYear W20596174082019 @default.
- W2059617408 crossrefType "journal-article" @default.
- W2059617408 hasAuthorship W2059617408A5010924510 @default.
- W2059617408 hasAuthorship W2059617408A5063344555 @default.
- W2059617408 hasConcept C121332964 @default.
- W2059617408 hasConcept C12554922 @default.
- W2059617408 hasConcept C136229726 @default.
- W2059617408 hasConcept C148898269 @default.
- W2059617408 hasConcept C185592680 @default.
- W2059617408 hasConcept C192562407 @default.
- W2059617408 hasConcept C203014093 @default.
- W2059617408 hasConcept C2777292125 @default.
- W2059617408 hasConcept C2778258694 @default.
- W2059617408 hasConcept C2779036427 @default.
- W2059617408 hasConcept C54173615 @default.
- W2059617408 hasConcept C55493867 @default.
- W2059617408 hasConcept C62520636 @default.
- W2059617408 hasConcept C71924100 @default.
- W2059617408 hasConcept C86803240 @default.
- W2059617408 hasConcept C89560881 @default.
- W2059617408 hasConceptScore W2059617408C121332964 @default.
- W2059617408 hasConceptScore W2059617408C12554922 @default.
- W2059617408 hasConceptScore W2059617408C136229726 @default.
- W2059617408 hasConceptScore W2059617408C148898269 @default.
- W2059617408 hasConceptScore W2059617408C185592680 @default.
- W2059617408 hasConceptScore W2059617408C192562407 @default.
- W2059617408 hasConceptScore W2059617408C203014093 @default.
- W2059617408 hasConceptScore W2059617408C2777292125 @default.
- W2059617408 hasConceptScore W2059617408C2778258694 @default.
- W2059617408 hasConceptScore W2059617408C2779036427 @default.
- W2059617408 hasConceptScore W2059617408C54173615 @default.
- W2059617408 hasConceptScore W2059617408C55493867 @default.
- W2059617408 hasConceptScore W2059617408C62520636 @default.
- W2059617408 hasConceptScore W2059617408C71924100 @default.
- W2059617408 hasConceptScore W2059617408C86803240 @default.
- W2059617408 hasConceptScore W2059617408C89560881 @default.
- W2059617408 hasIssue "1" @default.
- W2059617408 hasLocation W20596174081 @default.
- W2059617408 hasLocation W20596174082 @default.
- W2059617408 hasOpenAccess W2059617408 @default.
- W2059617408 hasPrimaryLocation W20596174081 @default.
- W2059617408 hasRelatedWork W1972585653 @default.
- W2059617408 hasRelatedWork W1985030818 @default.
- W2059617408 hasRelatedWork W2093700531 @default.
- W2059617408 hasRelatedWork W2102869383 @default.
- W2059617408 hasRelatedWork W2143521469 @default.
- W2059617408 hasRelatedWork W2408782384 @default.
- W2059617408 hasRelatedWork W2413494355 @default.
- W2059617408 hasRelatedWork W2516711089 @default.
- W2059617408 hasRelatedWork W3132482680 @default.
- W2059617408 hasRelatedWork W621194568 @default.
- W2059617408 hasVolume "4" @default.
- W2059617408 isParatext "false" @default.
- W2059617408 isRetracted "false" @default.
- W2059617408 magId "2059617408" @default.
- W2059617408 workType "article" @default.