FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059622010> ?p ?o ?g. }

• W2059622010 endingPage "4692" @default.
• W2059622010 startingPage "4683" @default.
• W2059622010 abstract "Differences involving serine residues in the sequence of the carboxyl-terminal tail of type 1 angiotensin II (Ang II) receptor subtypes AT(1A) and AT(1B) suggest differences in desensitization ability. We examined the Ang II-induced homologous desensitization patterns of both receptor subtypes in freshly isolated renal structures: glomerulus (Glom), afferent arteriole, and cortical thick ascending limb (CTAL), whose content in each subtype mRNA is different, by measuring variations in intracellular calcium concentration. A preexposure to a maximal dose of Ang II, followed by a second application of the same concentration, induced: 1) a complete desensitization in Glom, where AT(1A) and AT(1B) mRNAs were expressed in similar proportions, and 2) no or partial desensitization in afferent arteriole and CTAL, where AT(1A) mRNA was predominant. In the absence of nephron structure containing only AT(1B) mRNA, we studied rat anterior pituitary cells that exhibit high content in this subtype and observed that desensitization was not complete. In Glom, CTAL, and pituitary cells, desensitization proceeded in a dose-dependent manner. In Glom and CTAL, desensitization occurred via a PKC-independent mechanism. These results suggest that desensitization does not depend on the nature of Ang II receptor subtype but either on the proportion of each subtype in a given cell and/or on cell specific type. This could allow adaptive biological responses to Ang II appropriate to the specific function of a given cell type." @default.
• W2059622010 created "2016-06-24" @default.
• W2059622010 creator A5003063897 @default.
• W2059622010 creator A5025954230 @default.
• W2059622010 creator A5038470733 @default.
• W2059622010 creator A5043691599 @default.
• W2059622010 creator A5050530276 @default.
• W2059622010 creator A5068964290 @default.
• W2059622010 creator A5069996257 @default.
• W2059622010 creator A5070519498 @default.
• W2059622010 date "2001-11-01" @default.
• W2059622010 modified "2023-10-18" @default.
• W2059622010 title "Desensitization of Type 1 Angiotensin II Receptor Subtypes in the Rat Kidney" @default.
• W2059622010 cites W1515416907 @default.
• W2059622010 cites W1559798894 @default.
• W2059622010 cites W1965570459 @default.
• W2059622010 cites W1965773147 @default.
• W2059622010 cites W1966163552 @default.
• W2059622010 cites W1970573495 @default.
• W2059622010 cites W1974960382 @default.
• W2059622010 cites W1975712226 @default.
• W2059622010 cites W1976637929 @default.
• W2059622010 cites W1977479890 @default.
• W2059622010 cites W1979418469 @default.
• W2059622010 cites W1980258438 @default.
• W2059622010 cites W1983974889 @default.
• W2059622010 cites W1986251325 @default.
• W2059622010 cites W1989009278 @default.
• W2059622010 cites W1992884654 @default.
• W2059622010 cites W1999156171 @default.
• W2059622010 cites W2004698172 @default.
• W2059622010 cites W2010691086 @default.
• W2059622010 cites W2012207889 @default.
• W2059622010 cites W2012480726 @default.
• W2059622010 cites W2017592023 @default.
• W2059622010 cites W2029017148 @default.
• W2059622010 cites W2037628584 @default.
• W2059622010 cites W2042726226 @default.
• W2059622010 cites W2043623738 @default.
• W2059622010 cites W2045209465 @default.
• W2059622010 cites W2051185167 @default.
• W2059622010 cites W2053072327 @default.
• W2059622010 cites W2053476752 @default.
• W2059622010 cites W2060275422 @default.
• W2059622010 cites W2064098156 @default.
• W2059622010 cites W2068654607 @default.
• W2059622010 cites W2071216374 @default.
• W2059622010 cites W2086389958 @default.
• W2059622010 cites W2089025918 @default.
• W2059622010 cites W2093755801 @default.
• W2059622010 cites W2095364526 @default.
• W2059622010 cites W2095441352 @default.
• W2059622010 cites W2105767037 @default.
• W2059622010 cites W2108132405 @default.
• W2059622010 cites W2110659385 @default.
• W2059622010 cites W2111780029 @default.
• W2059622010 cites W2114224597 @default.
• W2059622010 cites W2123482117 @default.
• W2059622010 cites W2125438338 @default.
• W2059622010 cites W2175729515 @default.
• W2059622010 cites W2262670595 @default.
• W2059622010 cites W4248617605 @default.
• W2059622010 doi "https://doi.org/10.1210/endo.142.11.8485" @default.
• W2059622010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11606433" @default.
• W2059622010 hasPublicationYear "2001" @default.
• W2059622010 type Work @default.
• W2059622010 sameAs 2059622010 @default.
• W2059622010 citedByCount "6" @default.
• W2059622010 countsByYear W20596220102017 @default.
• W2059622010 crossrefType "journal-article" @default.
• W2059622010 hasAuthorship W2059622010A5003063897 @default.
• W2059622010 hasAuthorship W2059622010A5025954230 @default.
• W2059622010 hasAuthorship W2059622010A5038470733 @default.
• W2059622010 hasAuthorship W2059622010A5043691599 @default.
• W2059622010 hasAuthorship W2059622010A5050530276 @default.
• W2059622010 hasAuthorship W2059622010A5068964290 @default.
• W2059622010 hasAuthorship W2059622010A5069996257 @default.
• W2059622010 hasAuthorship W2059622010A5070519498 @default.
• W2059622010 hasBestOaLocation W20596220101 @default.
• W2059622010 hasConcept C126322002 @default.
• W2059622010 hasConcept C134018914 @default.
• W2059622010 hasConcept C170493617 @default.
• W2059622010 hasConcept C198710026 @default.
• W2059622010 hasConcept C2779779143 @default.
• W2059622010 hasConcept C2780091579 @default.
• W2059622010 hasConcept C2780636983 @default.
• W2059622010 hasConcept C2781231759 @default.
• W2059622010 hasConcept C2908929049 @default.
• W2059622010 hasConcept C71924100 @default.
• W2059622010 hasConcept C84393581 @default.
• W2059622010 hasConcept C86803240 @default.
• W2059622010 hasConcept C92759361 @default.
• W2059622010 hasConceptScore W2059622010C126322002 @default.
• W2059622010 hasConceptScore W2059622010C134018914 @default.
• W2059622010 hasConceptScore W2059622010C170493617 @default.
• W2059622010 hasConceptScore W2059622010C198710026 @default.
• W2059622010 hasConceptScore W2059622010C2779779143 @default.
• W2059622010 hasConceptScore W2059622010C2780091579 @default.

• next