FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059628085> ?p ?o ?g. }

• W2059628085 endingPage "1943" @default.
• W2059628085 startingPage "1932" @default.
• W2059628085 abstract "Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors play instrumental roles in embryonic organogenesis and diseases of adult organs. In particular, platelet-derived growth factor receptor-alpha (PDGFRα) is expressed by multipotent cardiovascular progenitors in mouse and human embryonic stem cell systems. Although cardiac PDGFRα expression has been studied in multiple species, little is known about its expression in the human heart. Using immunofluorescence, we analyzed PDGFRα expression in both human fetal and diseased adult hearts, finding strong expression in the interstitial cells of the epicardium, myocardium, and endocardium, as well as the coronary smooth muscle. Only rare endothelial cells and cardiomyocytes expressed PDGFRα. This pattern was consistent for both the fetal and adult diseased hearts, although more PDGFRα+ cardiomyocytes were noted in the latter. In vitro differentiation assays were then performed on the PDGFRα+ cell fraction isolated from the cardiomyocyte-depleted human fetal hearts. Protocols previously reported to direct differentiation to a cardiomyocyte (5-azacytidine), smooth muscle (PDGF-BB), or endothelial cell fates (vascular endothelial growth factor [VEGF]) were used. Although no significant cardiomyocyte differentiation was observed, PDGFRα+ cells generated significant numbers of smooth muscle cells (smooth muscle-α-actin+ and smooth muscle myosin+) and endothelial cells (CD31+). These data suggest that a subfraction of the cardiac PDGFRα+ populations are progenitors contributing predominantly to the vascular and mesenchymal compartments of the human heart. It may be possible to control the fate of these progenitors to promote vascularization or limit fibrosis in the injured heart." @default.
• W2059628085 created "2016-06-24" @default.
• W2059628085 creator A5000140761 @default.
• W2059628085 creator A5008632674 @default.
• W2059628085 creator A5033997989 @default.
• W2059628085 creator A5049289430 @default.
• W2059628085 creator A5062057628 @default.
• W2059628085 creator A5077140689 @default.
• W2059628085 date "2013-07-01" @default.
• W2059628085 modified "2023-10-03" @default.
• W2059628085 title "Progenitor Cells Identified by PDGFR-Alpha Expression in the Developing and Diseased Human Heart" @default.
• W2059628085 cites W1512987131 @default.
• W2059628085 cites W16118817 @default.
• W2059628085 cites W1977025496 @default.
• W2059628085 cites W1979155684 @default.
• W2059628085 cites W1979782761 @default.
• W2059628085 cites W1980537775 @default.
• W2059628085 cites W1981889540 @default.
• W2059628085 cites W1988451304 @default.
• W2059628085 cites W1989956666 @default.
• W2059628085 cites W2000168964 @default.
• W2059628085 cites W2005133052 @default.
• W2059628085 cites W2005435367 @default.
• W2059628085 cites W2006482057 @default.
• W2059628085 cites W2008016893 @default.
• W2059628085 cites W2010947763 @default.
• W2059628085 cites W2020876158 @default.
• W2059628085 cites W2028036560 @default.
• W2059628085 cites W2030176372 @default.
• W2059628085 cites W2055752082 @default.
• W2059628085 cites W2059984016 @default.
• W2059628085 cites W2070772918 @default.
• W2059628085 cites W2072386632 @default.
• W2059628085 cites W2074431288 @default.
• W2059628085 cites W2084114216 @default.
• W2059628085 cites W2098590189 @default.
• W2059628085 cites W2102525690 @default.
• W2059628085 cites W2112395856 @default.
• W2059628085 cites W2120856680 @default.
• W2059628085 cites W2122972967 @default.
• W2059628085 cites W2131388270 @default.
• W2059628085 cites W2132735690 @default.
• W2059628085 cites W2148402694 @default.
• W2059628085 cites W2149442576 @default.
• W2059628085 cites W2153560114 @default.
• W2059628085 cites W2155214429 @default.
• W2059628085 cites W2165160576 @default.
• W2059628085 cites W4211016865 @default.
• W2059628085 cites W4245465399 @default.
• W2059628085 doi "https://doi.org/10.1089/scd.2012.0542" @default.
• W2059628085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3685392" @default.
• W2059628085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23391309" @default.
• W2059628085 hasPublicationYear "2013" @default.
• W2059628085 type Work @default.
• W2059628085 sameAs 2059628085 @default.
• W2059628085 citedByCount "120" @default.
• W2059628085 countsByYear W20596280852013 @default.
• W2059628085 countsByYear W20596280852014 @default.
• W2059628085 countsByYear W20596280852015 @default.
• W2059628085 countsByYear W20596280852016 @default.
• W2059628085 countsByYear W20596280852017 @default.
• W2059628085 countsByYear W20596280852018 @default.
• W2059628085 countsByYear W20596280852019 @default.
• W2059628085 countsByYear W20596280852020 @default.
• W2059628085 countsByYear W20596280852021 @default.
• W2059628085 countsByYear W20596280852022 @default.
• W2059628085 countsByYear W20596280852023 @default.
• W2059628085 crossrefType "journal-article" @default.
• W2059628085 hasAuthorship W2059628085A5000140761 @default.
• W2059628085 hasAuthorship W2059628085A5008632674 @default.
• W2059628085 hasAuthorship W2059628085A5033997989 @default.
• W2059628085 hasAuthorship W2059628085A5049289430 @default.
• W2059628085 hasAuthorship W2059628085A5062057628 @default.
• W2059628085 hasAuthorship W2059628085A5077140689 @default.
• W2059628085 hasBestOaLocation W20596280852 @default.
• W2059628085 hasConcept C104317684 @default.
• W2059628085 hasConcept C111758988 @default.
• W2059628085 hasConcept C123012128 @default.
• W2059628085 hasConcept C126322002 @default.
• W2059628085 hasConcept C134018914 @default.
• W2059628085 hasConcept C145103041 @default.
• W2059628085 hasConcept C170493617 @default.
• W2059628085 hasConcept C180361614 @default.
• W2059628085 hasConcept C201750760 @default.
• W2059628085 hasConcept C202751555 @default.
• W2059628085 hasConcept C207200792 @default.
• W2059628085 hasConcept C2775960820 @default.
• W2059628085 hasConcept C2779395532 @default.
• W2059628085 hasConcept C2780394083 @default.
• W2059628085 hasConcept C2781294074 @default.
• W2059628085 hasConcept C28328180 @default.
• W2059628085 hasConcept C2992686903 @default.
• W2059628085 hasConcept C502942594 @default.
• W2059628085 hasConcept C55493867 @default.
• W2059628085 hasConcept C71924100 @default.
• W2059628085 hasConcept C85378888 @default.
• W2059628085 hasConcept C86803240 @default.
• W2059628085 hasConcept C95444343 @default.

• next