Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059629504> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2059629504 endingPage "2144" @default.
- W2059629504 startingPage "2137" @default.
- W2059629504 abstract "Two forms of cytosolic acetyltransferases, AT-I and AT-II, have been purified from hamster livers, and a comparison made of their chemical and catalytic properties and genetically expressed difference. Homogeneous AT-I and AT-II were 31 and 30 kd respectively on SDS-PAGE and catalyzed efficiently various N- and O-acetylatlons in their reconstitution systems. AT-I used both acetyl CoA and arylhydroxamic acids as acetyl donors, while AT-II did not utilize aryihydroxamic acids as acetyl donors. In the reconstitution system, purified AT-I, but not AT-II, catalyzed acetyl CoA-dependent 0-acetylation of 2-N-hydroxyamlno-6-methyldipyrido [1,2-α:3′,2′-d]imidazole (N-OH-Glu-P-1) and aryihydroxainic acid- dependent N-acetytation of 4-amlnoazobenzene (AAB). On the other hand purified AT-II showed high activities of acetyl CoA-dependent N-acetylation of 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). Polyclonal antibodies raised against AT-I inhibited cytosolic acetylations of N-OH-Glu P-1 and AAB, and to a lesser extent of AF, while PABA N-acetylatlon was only marginally inhibited. Using Western blots, both AT-I and AT-II were recognized by the antibodies. AT-I was detectable in all the livers examined, and the content did not differ among the individuals (monomorphic distribution). In contrast, AT-II was distributed polymor phically, and the trimodal distribution of AT-II (high, intermediate and low) was correlated with the phenotype identified by cytosolic N-acetylations of AF and PABA (rapid, intermediate and slow). In addition, cross-mating experiments with intra- and inter-phenotype animals confirmed that hepatic AT-II isozyme is inherited by a Mendelian co dominant trait. These results indicate that the polymorphic appearance of an acetyltransferase, AT-II, is responsible for the N-acetylation polymorphism in individual hamsters." @default.
- W2059629504 created "2016-06-24" @default.
- W2059629504 creator A5007422276 @default.
- W2059629504 creator A5030517670 @default.
- W2059629504 creator A5039577158 @default.
- W2059629504 creator A5044538377 @default.
- W2059629504 creator A5046966028 @default.
- W2059629504 creator A5069722397 @default.
- W2059629504 date "1990-01-01" @default.
- W2059629504 modified "2023-10-16" @default.
- W2059629504 title "Monomorphic and polymorphic isozymes of arylamine <i>N</i>-acetyltransferases inhamster liver: purification of the isozymes and genetic basis of <i>N</i>-acetylation polymorphism" @default.
- W2059629504 doi "https://doi.org/10.1093/carcin/11.12.2137" @default.
- W2059629504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2265466" @default.
- W2059629504 hasPublicationYear "1990" @default.
- W2059629504 type Work @default.
- W2059629504 sameAs 2059629504 @default.
- W2059629504 citedByCount "29" @default.
- W2059629504 countsByYear W20596295042019 @default.
- W2059629504 crossrefType "journal-article" @default.
- W2059629504 hasAuthorship W2059629504A5007422276 @default.
- W2059629504 hasAuthorship W2059629504A5030517670 @default.
- W2059629504 hasAuthorship W2059629504A5039577158 @default.
- W2059629504 hasAuthorship W2059629504A5044538377 @default.
- W2059629504 hasAuthorship W2059629504A5046966028 @default.
- W2059629504 hasAuthorship W2059629504A5069722397 @default.
- W2059629504 hasConcept C104317684 @default.
- W2059629504 hasConcept C119157956 @default.
- W2059629504 hasConcept C119795356 @default.
- W2059629504 hasConcept C153911025 @default.
- W2059629504 hasConcept C159654299 @default.
- W2059629504 hasConcept C181199279 @default.
- W2059629504 hasConcept C185592680 @default.
- W2059629504 hasConcept C198348125 @default.
- W2059629504 hasConcept C2778328694 @default.
- W2059629504 hasConcept C2910274206 @default.
- W2059629504 hasConcept C2910921701 @default.
- W2059629504 hasConcept C54355233 @default.
- W2059629504 hasConcept C55493867 @default.
- W2059629504 hasConcept C86803240 @default.
- W2059629504 hasConcept C956191 @default.
- W2059629504 hasConcept C98539663 @default.
- W2059629504 hasConceptScore W2059629504C104317684 @default.
- W2059629504 hasConceptScore W2059629504C119157956 @default.
- W2059629504 hasConceptScore W2059629504C119795356 @default.
- W2059629504 hasConceptScore W2059629504C153911025 @default.
- W2059629504 hasConceptScore W2059629504C159654299 @default.
- W2059629504 hasConceptScore W2059629504C181199279 @default.
- W2059629504 hasConceptScore W2059629504C185592680 @default.
- W2059629504 hasConceptScore W2059629504C198348125 @default.
- W2059629504 hasConceptScore W2059629504C2778328694 @default.
- W2059629504 hasConceptScore W2059629504C2910274206 @default.
- W2059629504 hasConceptScore W2059629504C2910921701 @default.
- W2059629504 hasConceptScore W2059629504C54355233 @default.
- W2059629504 hasConceptScore W2059629504C55493867 @default.
- W2059629504 hasConceptScore W2059629504C86803240 @default.
- W2059629504 hasConceptScore W2059629504C956191 @default.
- W2059629504 hasConceptScore W2059629504C98539663 @default.
- W2059629504 hasIssue "12" @default.
- W2059629504 hasLocation W20596295041 @default.
- W2059629504 hasLocation W20596295042 @default.
- W2059629504 hasOpenAccess W2059629504 @default.
- W2059629504 hasPrimaryLocation W20596295041 @default.
- W2059629504 hasRelatedWork W1763215782 @default.
- W2059629504 hasRelatedWork W1986393148 @default.
- W2059629504 hasRelatedWork W2009813704 @default.
- W2059629504 hasRelatedWork W2036965748 @default.
- W2059629504 hasRelatedWork W2059629504 @default.
- W2059629504 hasRelatedWork W2060038873 @default.
- W2059629504 hasRelatedWork W2118375848 @default.
- W2059629504 hasRelatedWork W2435599029 @default.
- W2059629504 hasRelatedWork W2610664061 @default.
- W2059629504 hasRelatedWork W288037188 @default.
- W2059629504 hasVolume "11" @default.
- W2059629504 isParatext "false" @default.
- W2059629504 isRetracted "false" @default.
- W2059629504 magId "2059629504" @default.
- W2059629504 workType "article" @default.