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- W2059631470 abstract "Abstract Alcohols 14 and 21 and the derived half-glutarate esters 15 and 22 have been prepared and evaluated as inhibitors of HMG CoA reductase. Compound 14 , the hexalin moiety of the natural fungal metabolite compactin (ML-236B) and compound 21 , its isomeric diene, have essentially no inhibitory properties. Compounds 15 and 22 show definite activity, although several orders of magnitude lower than that shown by compactin." @default.
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- W2059631470 date "1982-01-01" @default.
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- W2059631470 title "Synthesis and biological activity of the hexalin moiety of compactin (ML-236B)" @default.
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- W2059631470 doi "https://doi.org/10.1016/s0040-4039(00)85703-2" @default.
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