FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059635174> ?p ?o ?g. }

• W2059635174 endingPage "7142" @default.
• W2059635174 startingPage "7136" @default.
• W2059635174 abstract "Abstract Radiotherapy is one of the major treatment modalities for lung cancer. Cell killing by ionizing radiation is mediated primarily through the reactive oxygen species (ROS) and ROS-driven oxidative stress. Prx1, a peroxiredoxin family member, was shown to be frequently elevated in lung cancer cells and tissues. Although the antioxidant function of Prx1 is expected to affect the radiotherapy response of lung cancer, the physiologic significance of its peroxidase activity in irradiated cells is unclear because the catalytic Cys52 is easily inactivated by ROS due to its overoxidation to sulfinic or sulfonic acid. In this study, we investigated the role of Prx1 in radiation sensitivity of human lung cancer cells, with special emphasis on the redox status of the catalytic Cys52. We found that overexpression of Prx1 enhances the clonogenic survival of irradiated cells and suppresses ionizing radiation–induced c-Jun NH2-terminal kinase (JNK) activation and apoptosis. The peroxidase activity of Prx1, however, is not essential for inhibiting JNK activation. The latter effect is mediated through its association with the glutathione S-transferase pi (GSTpi)-JNK complex, thereby preventing JNK release from the complex. Reduced JNK activation is observed when the peroxidase activity of Prx1 is compromised by Cys52 overoxidation or in the presence of the Cys52 to Ser52 mutant (Prx1C52S) lacking peroxidase activity. We show that both Prx1 and Prx1C52S interact with the GSTpi-JNK complex and suppress the release of JNK from the complex. Our study provides new insight into the antiapoptotic function of Prx1 in modulating radiosensitivity and provides the impetus to monitor the influence of Prx1 levels in the management of lung cancer. (Cancer Res 2006; 66(14): 7136-42)" @default.
• W2059635174 created "2016-06-24" @default.
• W2059635174 creator A5006982467 @default.
• W2059635174 creator A5018467910 @default.
• W2059635174 creator A5022723594 @default.
• W2059635174 creator A5034292100 @default.
• W2059635174 creator A5048573107 @default.
• W2059635174 creator A5084652121 @default.
• W2059635174 date "2006-07-15" @default.
• W2059635174 modified "2023-10-03" @default.
• W2059635174 title "Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione <i>S</i>-Transferase Pi/c-Jun NH2-Terminal Kinase Complex" @default.
• W2059635174 cites W1484105951 @default.
• W2059635174 cites W1528630840 @default.
• W2059635174 cites W1775749144 @default.
• W2059635174 cites W1868897194 @default.
• W2059635174 cites W1968512956 @default.
• W2059635174 cites W1975695039 @default.
• W2059635174 cites W1986060421 @default.
• W2059635174 cites W1990348497 @default.
• W2059635174 cites W1991821808 @default.
• W2059635174 cites W1993058298 @default.
• W2059635174 cites W1994500027 @default.
• W2059635174 cites W1995963105 @default.
• W2059635174 cites W2001923529 @default.
• W2059635174 cites W2008144053 @default.
• W2059635174 cites W2008203769 @default.
• W2059635174 cites W2010397777 @default.
• W2059635174 cites W2012907539 @default.
• W2059635174 cites W2013815403 @default.
• W2059635174 cites W2017265125 @default.
• W2059635174 cites W2025306492 @default.
• W2059635174 cites W2030318378 @default.
• W2059635174 cites W2031767044 @default.
• W2059635174 cites W2034580062 @default.
• W2059635174 cites W2037840011 @default.
• W2059635174 cites W2038060960 @default.
• W2059635174 cites W2038415264 @default.
• W2059635174 cites W2043929237 @default.
• W2059635174 cites W2049048127 @default.
• W2059635174 cites W2059700063 @default.
• W2059635174 cites W2061972685 @default.
• W2059635174 cites W2062901635 @default.
• W2059635174 cites W2066946040 @default.
• W2059635174 cites W2069480316 @default.
• W2059635174 cites W2076515532 @default.
• W2059635174 cites W2098039543 @default.
• W2059635174 cites W2098048169 @default.
• W2059635174 cites W2099981464 @default.
• W2059635174 cites W2135917535 @default.
• W2059635174 cites W2144714494 @default.
• W2059635174 cites W2147228426 @default.
• W2059635174 cites W2147785354 @default.
• W2059635174 cites W2150081412 @default.
• W2059635174 cites W2158496331 @default.
• W2059635174 doi "https://doi.org/10.1158/0008-5472.can-05-4446" @default.
• W2059635174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16849559" @default.
• W2059635174 hasPublicationYear "2006" @default.
• W2059635174 type Work @default.
• W2059635174 sameAs 2059635174 @default.
• W2059635174 citedByCount "135" @default.
• W2059635174 countsByYear W20596351742012 @default.
• W2059635174 countsByYear W20596351742013 @default.
• W2059635174 countsByYear W20596351742014 @default.
• W2059635174 countsByYear W20596351742015 @default.
• W2059635174 countsByYear W20596351742016 @default.
• W2059635174 countsByYear W20596351742017 @default.
• W2059635174 countsByYear W20596351742018 @default.
• W2059635174 countsByYear W20596351742019 @default.
• W2059635174 countsByYear W20596351742020 @default.
• W2059635174 countsByYear W20596351742021 @default.
• W2059635174 countsByYear W20596351742022 @default.
• W2059635174 countsByYear W20596351742023 @default.
• W2059635174 crossrefType "journal-article" @default.
• W2059635174 hasAuthorship W2059635174A5006982467 @default.
• W2059635174 hasAuthorship W2059635174A5018467910 @default.
• W2059635174 hasAuthorship W2059635174A5022723594 @default.
• W2059635174 hasAuthorship W2059635174A5034292100 @default.
• W2059635174 hasAuthorship W2059635174A5048573107 @default.
• W2059635174 hasAuthorship W2059635174A5084652121 @default.
• W2059635174 hasConcept C104317684 @default.
• W2059635174 hasConcept C126322002 @default.
• W2059635174 hasConcept C184235292 @default.
• W2059635174 hasConcept C185592680 @default.
• W2059635174 hasConcept C190283241 @default.
• W2059635174 hasConcept C2776151105 @default.
• W2059635174 hasConcept C2776256026 @default.
• W2059635174 hasConcept C2779087070 @default.
• W2059635174 hasConcept C48349386 @default.
• W2059635174 hasConcept C502942594 @default.
• W2059635174 hasConcept C55493867 @default.
• W2059635174 hasConcept C71924100 @default.
• W2059635174 hasConcept C81729549 @default.
• W2059635174 hasConcept C86339819 @default.
• W2059635174 hasConcept C86803240 @default.
• W2059635174 hasConcept C95444343 @default.
• W2059635174 hasConceptScore W2059635174C104317684 @default.
• W2059635174 hasConceptScore W2059635174C126322002 @default.
• W2059635174 hasConceptScore W2059635174C184235292 @default.

• next