FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059638403> ?p ?o ?g. }

• W2059638403 endingPage "604" @default.
• W2059638403 startingPage "599" @default.
• W2059638403 abstract "Bronchial hyperresponsiveness to inhaled histamine in smokers is associated with an accelerated annual decline in FEV1 and low baseline FEV1 values. The evolution of bronchial hyperresponsiveness and whether it precedes or follows the accelerated decline in FEV1 and reduction in FEV1 is unknown. Measurements of the provocative concentration of inhaled histamine required to reduce FEV1 by 20% (PC20) were repeated after a four year interval in 27 male smokers (mean age 59 years, smoking on average 27 cigarettes a day in 1986) and 16 men who were ex-smokers in 1982 and who remained non-smokers until 1986 (mean age 53 years in 1986). These men were originally recruited to a prospective study in 1974 and had their first PC20 measurement in 1982. PC20 was positively related to baseline FEV1 in both smokers and ex-smokers in both 1982 and 1986 (r ranging from 0.56 to 0.76, p less than 0.01). In smokers mean FEV1 fell from 83% to 77% predicted (p less than 0.001) and geometric mean PC20 from 7.11 to 3.27 mg/ml (p less than 0.001) between 1982 and 1986. The change in PC20 in individual smokers over the four years was related to change in FEV1 (p = 0.012). In ex-smokers mean FEV1 was 93% predicted both in 1982 and in 1986 and there was no significant difference in geometric mean PC20 between 1982 (6.68 mg/ml) and 1986 (5.98 mg/ml). Thus in smokers there was an accelerated annual decline in FEV1 and an increase in bronchial hyperresponsiveness as FEV1 fell. The ex-smokers had comparable levels of bronchial hyperresponsiveness in 1982. Mean PC20 values were unchanged in 1986 in these men, who showed a normal age related decline in FEV1. These longitudinal results emphasise the importance of baseline airway geometry in influencing bronchial hyperresponsiveness to histamine in middle aged smokers and ex-smokers." @default.
• W2059638403 created "2016-06-24" @default.
• W2059638403 creator A5017458408 @default.
• W2059638403 creator A5031234195 @default.
• W2059638403 creator A5053716905 @default.
• W2059638403 creator A5059925446 @default.
• W2059638403 creator A5064282485 @default.
• W2059638403 date "1988-08-01" @default.
• W2059638403 modified "2023-10-11" @default.
• W2059638403 title "Changes in bronchial responsiveness to inhaled histamine over four years in middle aged male smokers and ex-smokers." @default.
• W2059638403 cites W1705185877 @default.
• W2059638403 cites W1765750524 @default.
• W2059638403 cites W1904291169 @default.
• W2059638403 cites W1956940855 @default.
• W2059638403 cites W1961136230 @default.
• W2059638403 cites W1964793578 @default.
• W2059638403 cites W1968268971 @default.
• W2059638403 cites W1977352423 @default.
• W2059638403 cites W1999226863 @default.
• W2059638403 cites W2055642641 @default.
• W2059638403 cites W2097147587 @default.
• W2059638403 cites W2125037307 @default.
• W2059638403 cites W2137401824 @default.
• W2059638403 cites W2183527245 @default.
• W2059638403 cites W2395601990 @default.
• W2059638403 cites W2405226386 @default.
• W2059638403 cites W2414545977 @default.
• W2059638403 cites W2436438641 @default.
• W2059638403 doi "https://doi.org/10.1136/thx.43.8.599" @default.
• W2059638403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/461394" @default.
• W2059638403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3175972" @default.
• W2059638403 hasPublicationYear "1988" @default.
• W2059638403 type Work @default.
• W2059638403 sameAs 2059638403 @default.
• W2059638403 citedByCount "31" @default.
• W2059638403 crossrefType "journal-article" @default.
• W2059638403 hasAuthorship W2059638403A5017458408 @default.
• W2059638403 hasAuthorship W2059638403A5031234195 @default.
• W2059638403 hasAuthorship W2059638403A5053716905 @default.
• W2059638403 hasAuthorship W2059638403A5059925446 @default.
• W2059638403 hasAuthorship W2059638403A5064282485 @default.
• W2059638403 hasBestOaLocation W20596384031 @default.
• W2059638403 hasConcept C105795698 @default.
• W2059638403 hasConcept C1122143 @default.
• W2059638403 hasConcept C126322002 @default.
• W2059638403 hasConcept C188816634 @default.
• W2059638403 hasConcept C2776042228 @default.
• W2059638403 hasConcept C2776178081 @default.
• W2059638403 hasConcept C2776238763 @default.
• W2059638403 hasConcept C2776954882 @default.
• W2059638403 hasConcept C2777714996 @default.
• W2059638403 hasConcept C33923547 @default.
• W2059638403 hasConcept C40222840 @default.
• W2059638403 hasConcept C42219234 @default.
• W2059638403 hasConcept C71924100 @default.
• W2059638403 hasConceptScore W2059638403C105795698 @default.
• W2059638403 hasConceptScore W2059638403C1122143 @default.
• W2059638403 hasConceptScore W2059638403C126322002 @default.
• W2059638403 hasConceptScore W2059638403C188816634 @default.
• W2059638403 hasConceptScore W2059638403C2776042228 @default.
• W2059638403 hasConceptScore W2059638403C2776178081 @default.
• W2059638403 hasConceptScore W2059638403C2776238763 @default.
• W2059638403 hasConceptScore W2059638403C2776954882 @default.
• W2059638403 hasConceptScore W2059638403C2777714996 @default.
• W2059638403 hasConceptScore W2059638403C33923547 @default.
• W2059638403 hasConceptScore W2059638403C40222840 @default.
• W2059638403 hasConceptScore W2059638403C42219234 @default.
• W2059638403 hasConceptScore W2059638403C71924100 @default.
• W2059638403 hasIssue "8" @default.
• W2059638403 hasLocation W20596384031 @default.
• W2059638403 hasLocation W20596384032 @default.
• W2059638403 hasLocation W20596384033 @default.
• W2059638403 hasLocation W20596384034 @default.
• W2059638403 hasOpenAccess W2059638403 @default.
• W2059638403 hasPrimaryLocation W20596384031 @default.
• W2059638403 hasRelatedWork W1997281330 @default.
• W2059638403 hasRelatedWork W2016016526 @default.
• W2059638403 hasRelatedWork W2046289896 @default.
• W2059638403 hasRelatedWork W2062538374 @default.
• W2059638403 hasRelatedWork W2135946482 @default.
• W2059638403 hasRelatedWork W2166706136 @default.
• W2059638403 hasRelatedWork W2390290657 @default.
• W2059638403 hasRelatedWork W2410049500 @default.
• W2059638403 hasRelatedWork W2419083282 @default.
• W2059638403 hasRelatedWork W4300224963 @default.
• W2059638403 hasVolume "43" @default.
• W2059638403 isParatext "false" @default.
• W2059638403 isRetracted "false" @default.
• W2059638403 magId "2059638403" @default.
• W2059638403 workType "article" @default.