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- W2059639333 endingPage "22018" @default.
- W2059639333 startingPage "22006" @default.
- W2059639333 abstract "The fungus Candida glabrata is an important and increasingly common pathogen of humans, particularly in immunocompromised hosts. Despite this, little is known about the attributes that allow this organism to cause disease or its interaction with the host immune system. However, in common with other fungi, the cell wall of C. glabrata is the initial point of contact between the host and pathogen, and as such, it is likely to play an important role in mediating interactions and hence virulence. Here, we show both through genetic complementation and polysaccharide structural analyses that C. glabrata ANP1, MNN2, and MNN11 encode functional orthologues of the respective Saccharomyces cerevisiae mannosyltransferases. Furthermore, we show that deletion of the C. glabrata Anp1, Mnn2, and Mnn11 mannosyltransferases directly affects the structure of the fungal N-linked mannan, in line with their predicted functions, and this has implications for cell wall integrity and consequently virulence. C. glabrata anp1 and mnn2 mutants showed increased virulence, compared with wild-type (and mnn11) cells. This is in contrast to Candida albicans where inactivation of genes involved in mannan biosynthesis has usually been linked to an attenuation of virulence. In the long term, a better understanding of the attributes that allow C. glabrata to cause disease will provide insights that can be adopted for the development of novel therapeutic and diagnostic approaches." @default.
- W2059639333 created "2016-06-24" @default.
- W2059639333 creator A5005840185 @default.
- W2059639333 creator A5008227126 @default.
- W2059639333 creator A5031129705 @default.
- W2059639333 creator A5033677559 @default.
- W2059639333 creator A5066689668 @default.
- W2059639333 creator A5084718162 @default.
- W2059639333 creator A5089100795 @default.
- W2059639333 creator A5089563977 @default.
- W2059639333 creator A5090644565 @default.
- W2059639333 date "2013-07-01" @default.
- W2059639333 modified "2023-10-05" @default.
- W2059639333 title "Differential Virulence of Candida glabrata Glycosylation Mutants" @default.
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