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- W2059644488 abstract "Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo><</mml:mo></mml:mrow></mml:math>32 weeks and birth weight<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo><</mml:mo><mml:mn>1500</mml:mn></mml:math> g) were consecutively included. MDA-Hb and blood glutathione (GSH) concentrations were measured by liquid chromatography-mass spectrometry during the first 6 weeks of life. Linear regressions and a multilevel model were fitted to study the relationship between MDA-Hb or GSH and ISM. Of the 83 PT (mean ± SD:<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn>28.3</mml:mn><mml:mo>±</mml:mo><mml:mn>2</mml:mn></mml:math>weeks,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn>1089</mml:mn><mml:mo>±</mml:mo><mml:mn>288</mml:mn></mml:math> g), 21% presented severe neonatal morbidity. In the multivariate model, MDA-Hb concentrations were significantly higher in the ISM+ group than in the ISM– group during the first 6 weeks of life (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.009</mml:mn></mml:math>). No significant difference in GSH concentrations was observed between groups (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.180</mml:mn></mml:math>). MDA-Hb is a marker of interest for estimating oxidative stress in PT and could be useful to evaluate the impact of strategies to improve perinatal outcomes." @default.
- W2059644488 created "2016-06-24" @default.
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- W2059644488 date "2013-01-01" @default.
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- W2059644488 title "Adduct of Malondialdehyde to Hemoglobin: A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants" @default.
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- W2059644488 doi "https://doi.org/10.1155/2013/901253" @default.
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