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• W2059650287 abstract "Energy is the motor of life. Energy ensures the organism's survival and competitive advantage for reproductive success. For almost 3 billion years, unicellular organisms were the only life form on earth. Competition for limited energy resources and raw materials exerted an incessant selective pressure on organisms. In the adverse environment and due to their 'feast and famine' life style, hardiness to a variety of stressors, particularly to nutrient deprivation, was the selection principle. Both resistance and mutagenic adaptation to stressors were established as survival strategies by means of context-specific processes creating stability or variability of DNA sequence. The conservation of transduction pathways and functional homology of effector molecules clearly bear witness that the principles of life established during prokaryotic and eukaryotic unicellular evolution, although later diversified, have been unshakably cast to persist during metazoan phylogenesis. A wealth of evidence suggests that unicellular organisms evolved the phenomena of differentiation and apoptosis, sexual reproduction, and even aging, as responses to environmental challenges. These evolutionary accomplishments were elaborated from the dichotomous resistance/mutagenesis response and sophisticated the capacity of cells to tune their genetic information to changing environmental conditions. Notably, the social deprivation responses, differentiation and apoptosis, evolved as intercellularly coordinated events: a multitude of differentiation processes were elaborated from sporulation, the prototypic stress resistance response, while apoptosis, contrary to current concepts, is no altruistic cell suicide but was programmed as a mutagenic survival response; this response, however, is socially thwarted leading into mutagenic error catastrophe. In the hybrid differentiation-apoptosis process, cytocide and cannibalism of apoptotic cells thus serve the purpose of fueling the survival of the selfish genes in the differentiating cells. However, successful mutagenesis, although repressed, persisted in the asocial stress response of carcinogenesis as a regression to primitive unicellular behavior following failure of intercellular communication. While somatic mutagenesis was largely prevented, Metazoa elaborated germ cell mutagenesis as an evolutionary vehicle. Genetic competence, a primitive, stress-induced mating behavior, evolved into sexual reproduction which harnessed mutagenesis by subjecting highly mutable germ cells to a rigid viability selection. These processes were programmatically fixed as life- and cell-cycle events but retained their deprivation response phenotypes. Thus, the differentiation-apoptosis tandem evolved as the 'clay' to mold the specialized structures and functions of a multicellular organism while sexual reproduction elaborated the principle of quality-checked mutagenesis to create the immense diversity of Metazoa following the Cambrian explosion. Throughout these events, reactive oxygen and nitrogen species, which are regulated by energy homeostasis, shape the genetic information in a regulated but random, uncoded process providing the fitness-related feedback of phenotype to genotype. The interplay of genes and environment establishes a dynamic stimulus-response feedback cycle which, in animate nature, may be the organizing principle to contrive the reciprocal duality of energy and matter." @default.
• W2059650287 created "2016-06-24" @default.
• W2059650287 creator A5088738991 @default.
• W2059650287 date "2001-01-01" @default.
• W2059650287 modified "2023-10-17" @default.
• W2059650287 title "The Deprivation Syndrome is the Driving Force of Phylogeny, Ontogeny and Oncogeny" @default.
• W2059650287 cites W128826586 @default.
• W2059650287 cites W1451896083 @default.
• W2059650287 cites W1488489148 @default.
• W2059650287 cites W1550251645 @default.
• W2059650287 cites W1559768539 @default.
• W2059650287 cites W1564482286 @default.
• W2059650287 cites W1607112133 @default.
• W2059650287 cites W1643908226 @default.
• W2059650287 cites W165674593 @default.
• W2059650287 cites W1751530372 @default.
• W2059650287 cites W1833157201 @default.
• W2059650287 cites W1865873333 @default.
• W2059650287 cites W1866069027 @default.
• W2059650287 cites W1907294786 @default.
• W2059650287 cites W1913193691 @default.
• W2059650287 cites W1943998482 @default.
• W2059650287 cites W1967533913 @default.
• W2059650287 cites W1968354566 @default.
• W2059650287 cites W1968568980 @default.
• W2059650287 cites W1973306326 @default.
• W2059650287 cites W1973555052 @default.
• W2059650287 cites W1973735723 @default.
• W2059650287 cites W1975223491 @default.
• W2059650287 cites W1975548754 @default.
• W2059650287 cites W1976075077 @default.
• W2059650287 cites W1977488110 @default.
• W2059650287 cites W1980027584 @default.
• W2059650287 cites W1981513372 @default.
• W2059650287 cites W1981797176 @default.
• W2059650287 cites W1984373476 @default.
• W2059650287 cites W1984433655 @default.
• W2059650287 cites W1990085600 @default.
• W2059650287 cites W1990364432 @default.
• W2059650287 cites W1990665368 @default.
• W2059650287 cites W1992033907 @default.
• W2059650287 cites W1994127106 @default.
• W2059650287 cites W1995205975 @default.
• W2059650287 cites W1995994479 @default.
• W2059650287 cites W1997030336 @default.
• W2059650287 cites W1997797597 @default.
• W2059650287 cites W2002109198 @default.
• W2059650287 cites W2004322097 @default.
• W2059650287 cites W2007917116 @default.
• W2059650287 cites W2007939817 @default.
• W2059650287 cites W2011123924 @default.
• W2059650287 cites W2012556815 @default.
• W2059650287 cites W2014055734 @default.
• W2059650287 cites W2014642267 @default.
• W2059650287 cites W2022183036 @default.
• W2059650287 cites W2023665511 @default.
• W2059650287 cites W2024026979 @default.
• W2059650287 cites W2025128734 @default.
• W2059650287 cites W2030932036 @default.
• W2059650287 cites W2031252769 @default.
• W2059650287 cites W2033800625 @default.
• W2059650287 cites W2037267081 @default.
• W2059650287 cites W2038003361 @default.
• W2059650287 cites W2038334762 @default.
• W2059650287 cites W2040196552 @default.
• W2059650287 cites W2043639971 @default.
• W2059650287 cites W2044298023 @default.
• W2059650287 cites W2044839031 @default.
• W2059650287 cites W2048320278 @default.
• W2059650287 cites W2048339025 @default.
• W2059650287 cites W2049983551 @default.
• W2059650287 cites W2050992919 @default.
• W2059650287 cites W2051691998 @default.
• W2059650287 cites W2054287923 @default.
• W2059650287 cites W2061154169 @default.
• W2059650287 cites W2063806558 @default.
• W2059650287 cites W2067819328 @default.
• W2059650287 cites W2069094876 @default.
• W2059650287 cites W2069822709 @default.
• W2059650287 cites W2071421573 @default.
• W2059650287 cites W2073186504 @default.
• W2059650287 cites W2076624024 @default.
• W2059650287 cites W2085231219 @default.
• W2059650287 cites W2086759918 @default.
• W2059650287 cites W2087351233 @default.
• W2059650287 cites W2093074934 @default.
• W2059650287 cites W2094160630 @default.
• W2059650287 cites W2095146312 @default.
• W2059650287 cites W2097791161 @default.
• W2059650287 cites W2098882558 @default.
• W2059650287 cites W2103129136 @default.
• W2059650287 cites W2105224505 @default.
• W2059650287 cites W2110619496 @default.
• W2059650287 cites W2112318520 @default.
• W2059650287 cites W2113314251 @default.
• W2059650287 cites W2115890230 @default.
• W2059650287 cites W2116508133 @default.
• W2059650287 cites W2123400762 @default.
• W2059650287 cites W2123408027 @default.
• W2059650287 cites W2126403099 @default.

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