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• W2059652008 abstract "The interleukin-1 (IL-1) α and β precursor proteins are processed and released from several cell types in the absence of a canonical signal peptide. To gain some insight into the mechanisms that allow the production of IL-1α and β, we have investigated by immunoprecipitation the synthesis, their release and processing in a promieloblastic cell line of tumoral origin, U937, and in peripheral blood monocytes. We show that U937 monocytic cells, on induction with a tumor-promoting agent, synthesize and release into the culture medium proIL-1β but do not process it. Similarly, peripheral blood monocytes left in adherence for 24 h or longer, prior to addition of lipopolysaccharide, synthesize and release proIL-1α and β without detectable processing of either cytokine. Processing and release of IL-1α and β by peripheral blood monocytes can be observed when monocytes are left to adhere for periods less than 15 h before lipopolysaccharide addition. IL-1α and β show similar kinetics of release from the cells, suggesting the existence of a common mechanism regulating their secretion. Since peripheral blood monocytes left in adherence in the presence of lipopolysaccharide differentiate into macrophages, we conclude that release and processing of IL-1 can occur independently and that processing depends on the stage of differentiation of monocytes, i.e. only the monocytes at an early stage of differentiation produce 17-kDa IL-1α and β." @default.
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• W2059652008 date "1992-04-01" @default.
• W2059652008 modified "2023-09-25" @default.
• W2059652008 title "Processing of interleukin-1 in cells of monocytic lineage is differentiation-dependent" @default.
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• W2059652008 doi "https://doi.org/10.1111/j.1432-1033.1992.tb16780.x" @default.
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