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• W2059654328 abstract "Introduction Platelet-activating factor acetylhydrolase (PAF-AH or Lp-PLA2) is a Ca2+-independent phospholipase A2 primarily associated in plasma with low density lipoproteins (LDL), especially with small dense LDL (sdLDL) particles. Increased plasma Lp-PLA2 levels have been associated with increased cardiovascular risk in large clinical trials. Aim To assess the effects of weight loss on Lp-PLA2 activity and to examine the association of Lp-PLA2 activity changes with the alterations of sdLDL, the primary carrier of Lp-PLA2 in plasma. Methods Twenty-eight obese, non-diabetic women participated in a weight reduction program. Anthropometric parameters were assessed and parameters of glucose metabolism, lipid profile, Lp-PLA2 activity, and LDL phenotype (using a 3% polyacrylamide gel-tube electrophoresis method), were determined at baseline and after 4 months of weight loss. Results A 10% diet-induced weight loss resulted in significant improvement in most parameters of lipid and glucose metabolism. Moreover, Lp-PLA2 activity was significantly reduced (−10.2%, p < 0.01). Mean LDL particle diameter did not change after the weight loss program. The cholesterol levels of very low-density lipoprotein (VLDL) and large-buoyant LDL particles were significantly reduced, but neither the cholesterol levels of sdLDL particles nor the % proportion of the sdLDL-cholesterol over the total LDL-cholesterol were changed after the intervention program. Interestingly, the changes in Lp-PLA2 activity were correlated with the changes of VLDL-cholesterol (r = 0.39, p < 0.05), but not with the changes of anthropometric or other lipid variables. Conclusions A low-calorie diet associated with weight loss in obese women resulted in the significant reduction of the plasma levels of Lp-PLA2, the potentially new predictor for incident atherosclerotic disease." @default.
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• W2059654328 date "2008-09-01" @default.
• W2059654328 modified "2023-10-17" @default.
• W2059654328 title "Effects of a low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in healthy obese women" @default.
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• W2059654328 doi "https://doi.org/10.1016/j.numecd.2007.04.004" @default.
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