Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059656156> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2059656156 endingPage "988" @default.
- W2059656156 startingPage "988" @default.
- W2059656156 abstract "Pearl and nacre are valuable traditional medicines to treat palpitations, convulsions or epilepsy in China for thousands of years. However, the active ingredients are not clear till now.The main purpose of the current investigation was to assess the anticonvulsant and sedative–hypnotic activity of pearl powder and nacre powder, including their corresponding 6 protein extracts.Determination of the amino acid composition of the obtained protein was carried out by ultra-performance liquid chromatography (UPLC) combined with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) pre-column derivatisation. The influence of the tested drugs on locomotor activity and convulsions latency was recorded. The contents of 5-Hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA) in brain were detected by enzyme-linked immunesorbent assay (ELISA) kits. In addition, immunohistochemistry was carried out to evaluate the changes of 5-HT3 and GABAB. In parallel, the expressions of them were demonstrated by western blot.The obtained data suggested that pearl original powder (1.1 g/kg), pearl water-soluble protein (0.2 g/kg), pearl acid-soluble protein (0.275 g/kg), pearl conchiolin protein (1.1 g/kg), nacre original powder (1.1 g/kg), nacre water-soluble protein (0.2 g/kg), nacre acid-soluble protein (0.7 g/kg) and nacre conchiolin protein (1.1 g/kg) could down-regulate the expression of 5-HT3 and up-regulate the level of GABAB to varying degrees compared with the control group. Besides, drug administration also reduced the locomotor activity and increased convulsions latency with a certain mortality.These findings correlated with the traditional use of pearl and nacre as sedation and tranquilization agents, thus making them interesting sources for further drug development and also providing critical important evidence for the selection of quality control markers." @default.
- W2059656156 created "2016-06-24" @default.
- W2059656156 creator A5012680890 @default.
- W2059656156 creator A5022569896 @default.
- W2059656156 creator A5051071399 @default.
- W2059656156 creator A5064721182 @default.
- W2059656156 date "1989-01-01" @default.
- W2059656156 modified "2023-09-26" @default.
- W2059656156 title "Acoustic emission during compression from normal and diseased bone" @default.
- W2059656156 doi "https://doi.org/10.1016/0021-9290(89)90126-7" @default.
- W2059656156 hasPublicationYear "1989" @default.
- W2059656156 type Work @default.
- W2059656156 sameAs 2059656156 @default.
- W2059656156 citedByCount "0" @default.
- W2059656156 crossrefType "journal-article" @default.
- W2059656156 hasAuthorship W2059656156A5012680890 @default.
- W2059656156 hasAuthorship W2059656156A5022569896 @default.
- W2059656156 hasAuthorship W2059656156A5051071399 @default.
- W2059656156 hasAuthorship W2059656156A5064721182 @default.
- W2059656156 hasConcept C104317684 @default.
- W2059656156 hasConcept C118552586 @default.
- W2059656156 hasConcept C138885662 @default.
- W2059656156 hasConcept C179998833 @default.
- W2059656156 hasConcept C185592680 @default.
- W2059656156 hasConcept C27206212 @default.
- W2059656156 hasConcept C2775858608 @default.
- W2059656156 hasConcept C2776415932 @default.
- W2059656156 hasConcept C2777602617 @default.
- W2059656156 hasConcept C2778186239 @default.
- W2059656156 hasConcept C2779251273 @default.
- W2059656156 hasConcept C43617362 @default.
- W2059656156 hasConcept C55493867 @default.
- W2059656156 hasConcept C71924100 @default.
- W2059656156 hasConcept C98274493 @default.
- W2059656156 hasConceptScore W2059656156C104317684 @default.
- W2059656156 hasConceptScore W2059656156C118552586 @default.
- W2059656156 hasConceptScore W2059656156C138885662 @default.
- W2059656156 hasConceptScore W2059656156C179998833 @default.
- W2059656156 hasConceptScore W2059656156C185592680 @default.
- W2059656156 hasConceptScore W2059656156C27206212 @default.
- W2059656156 hasConceptScore W2059656156C2775858608 @default.
- W2059656156 hasConceptScore W2059656156C2776415932 @default.
- W2059656156 hasConceptScore W2059656156C2777602617 @default.
- W2059656156 hasConceptScore W2059656156C2778186239 @default.
- W2059656156 hasConceptScore W2059656156C2779251273 @default.
- W2059656156 hasConceptScore W2059656156C43617362 @default.
- W2059656156 hasConceptScore W2059656156C55493867 @default.
- W2059656156 hasConceptScore W2059656156C71924100 @default.
- W2059656156 hasConceptScore W2059656156C98274493 @default.
- W2059656156 hasIssue "10" @default.
- W2059656156 hasLocation W20596561561 @default.
- W2059656156 hasOpenAccess W2059656156 @default.
- W2059656156 hasPrimaryLocation W20596561561 @default.
- W2059656156 hasRelatedWork W1771027348 @default.
- W2059656156 hasRelatedWork W1970099699 @default.
- W2059656156 hasRelatedWork W2016925898 @default.
- W2059656156 hasRelatedWork W2052686354 @default.
- W2059656156 hasRelatedWork W2084439527 @default.
- W2059656156 hasRelatedWork W2120557693 @default.
- W2059656156 hasRelatedWork W2476525885 @default.
- W2059656156 hasRelatedWork W2736917669 @default.
- W2059656156 hasRelatedWork W2039734860 @default.
- W2059656156 hasRelatedWork W2174961586 @default.
- W2059656156 hasVolume "22" @default.
- W2059656156 isParatext "false" @default.
- W2059656156 isRetracted "false" @default.
- W2059656156 magId "2059656156" @default.
- W2059656156 workType "article" @default.