FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059656206> ?p ?o ?g. }

• W2059656206 endingPage "430" @default.
• W2059656206 startingPage "422" @default.
• W2059656206 abstract "In this placebo-controlled double-blind study, psychological and endocrine stress responses were investigated in healthy postmenopausal placebo-treated women (n = 15; 60-75 years; placebo via transdermal patches), healthy postmenopausal estradiol-treated women (n = 13; 60-79 years; 0.1 mg 17beta-estradiol daily via transdermal patches) and young controls (n = 15; 20-31 years; untreated). The aged subjects received estradiol or placebo treatment for 14 days. All subjects were then exposed to the 'Trier Social Stress Test' (TSST) and the dexamethasone (Dex)-human corticotropin-releasing hormone (hCRH) test (100 microgram hCRH after premedication with 1.5 mg Dex). Psychological parameters including perceived stressfulness, mood and subjective well-being were measured by visual analog scales, a mood questionnaire and a mood diary, respectively. Results show that the TSST induced significant increases in adrenocorticotropin (ACTH), free salivary cortisol, total plasma cortisol and heart rates (all p < 0.0001). Regardless of age, comparable hormonal response patterns were observed in the TSST as indicated by similar peak levels and recovery phases. Visual analog scales confirmed that the same amount of stress was experienced by young and elderly subjects. In both age groups, hCRH injection after Dex premedication provoked significant increases in ACTH, free salivary cortisol and total plasma cortisol (all p < 0.0001). In contrast to the psychosocial stressor, elderly women were found to respond with a markedly enhanced cortisol response compared to young controls in the Dex-CRH test (p < 0.025). Additional investigation of morning cortisol profiles could not reveal any age-related differences in basal hypothalamus-pituitary-adrenal (HPA) axis activity. Following estradiol treatment, estradiol levels significantly increased only in substituted postmenopausal women (p < 0.001) reaching concentrations typically found in younger women during the follicular phase of the menstrual cycle. Corticosteroid-binding globulin levels did not differ significantly between groups. When confronted with the TSST, no response differences emerged between the three groups. However, estradiol treatment appeared to blunt the total plasma cortisol response in the Dex-CRH test, resulting in smaller increases in untreated premenopausal women and estradiol-treated postmenopausal women compared to placebo-treated postmenopausal women (p < 0.02). In sum, no response differences were observed after confrontation with a psychosocial stress test in our sample of healthy elderly subjects. As shown with the Dex-CRH test, our data suggest that the negative feedback of the HPA axis in elderly women is altered. Moreover, the current data suggest that estradiol replacement may modulate HPA feedback sensitivity in humans." @default.
• W2059656206 created "2016-06-24" @default.
• W2059656206 creator A5045674246 @default.
• W2059656206 creator A5062791508 @default.
• W2059656206 creator A5083695665 @default.
• W2059656206 creator A5084148049 @default.
• W2059656206 date "1999-01-01" @default.
• W2059656206 modified "2023-10-16" @default.
• W2059656206 title "Psychological and Endocrine Responses to Psychosocial Stress and Dexamethasone/ Corticotropin-Releasing Hormone in Healthy Postmenopausal Women and Young Controls: The Impact of Age and a Two-Week Estradiol Treatment" @default.
• W2059656206 cites W1982951804 @default.
• W2059656206 cites W1988281595 @default.
• W2059656206 cites W1988575213 @default.
• W2059656206 cites W2018195755 @default.
• W2059656206 cites W2024052565 @default.
• W2059656206 cites W2036643530 @default.
• W2059656206 cites W2040476403 @default.
• W2059656206 cites W2132731742 @default.
• W2059656206 cites W4235505771 @default.
• W2059656206 cites W4237348831 @default.
• W2059656206 cites W4237897046 @default.
• W2059656206 doi "https://doi.org/10.1159/000054504" @default.
• W2059656206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10657735" @default.
• W2059656206 hasPublicationYear "1999" @default.
• W2059656206 type Work @default.
• W2059656206 sameAs 2059656206 @default.
• W2059656206 citedByCount "125" @default.
• W2059656206 countsByYear W20596562062012 @default.
• W2059656206 countsByYear W20596562062013 @default.
• W2059656206 countsByYear W20596562062014 @default.
• W2059656206 countsByYear W20596562062015 @default.
• W2059656206 countsByYear W20596562062016 @default.
• W2059656206 countsByYear W20596562062017 @default.
• W2059656206 countsByYear W20596562062018 @default.
• W2059656206 countsByYear W20596562062019 @default.
• W2059656206 countsByYear W20596562062020 @default.
• W2059656206 countsByYear W20596562062021 @default.
• W2059656206 countsByYear W20596562062023 @default.
• W2059656206 crossrefType "journal-article" @default.
• W2059656206 hasAuthorship W2059656206A5045674246 @default.
• W2059656206 hasAuthorship W2059656206A5062791508 @default.
• W2059656206 hasAuthorship W2059656206A5083695665 @default.
• W2059656206 hasAuthorship W2059656206A5084148049 @default.
• W2059656206 hasConcept C104317684 @default.
• W2059656206 hasConcept C118552586 @default.
• W2059656206 hasConcept C126322002 @default.
• W2059656206 hasConcept C134018914 @default.
• W2059656206 hasConcept C142724271 @default.
• W2059656206 hasConcept C15744967 @default.
• W2059656206 hasConcept C185592680 @default.
• W2059656206 hasConcept C204787440 @default.
• W2059656206 hasConcept C27081682 @default.
• W2059656206 hasConcept C2778458438 @default.
• W2059656206 hasConcept C2778597338 @default.
• W2059656206 hasConcept C2778709874 @default.
• W2059656206 hasConcept C2779064019 @default.
• W2059656206 hasConcept C2780546910 @default.
• W2059656206 hasConcept C2780733359 @default.
• W2059656206 hasConcept C2780841215 @default.
• W2059656206 hasConcept C55493867 @default.
• W2059656206 hasConcept C62913699 @default.
• W2059656206 hasConcept C71315377 @default.
• W2059656206 hasConcept C71924100 @default.
• W2059656206 hasConcept C78604142 @default.
• W2059656206 hasConceptScore W2059656206C104317684 @default.
• W2059656206 hasConceptScore W2059656206C118552586 @default.
• W2059656206 hasConceptScore W2059656206C126322002 @default.
• W2059656206 hasConceptScore W2059656206C134018914 @default.
• W2059656206 hasConceptScore W2059656206C142724271 @default.
• W2059656206 hasConceptScore W2059656206C15744967 @default.
• W2059656206 hasConceptScore W2059656206C185592680 @default.
• W2059656206 hasConceptScore W2059656206C204787440 @default.
• W2059656206 hasConceptScore W2059656206C27081682 @default.
• W2059656206 hasConceptScore W2059656206C2778458438 @default.
• W2059656206 hasConceptScore W2059656206C2778597338 @default.
• W2059656206 hasConceptScore W2059656206C2778709874 @default.
• W2059656206 hasConceptScore W2059656206C2779064019 @default.
• W2059656206 hasConceptScore W2059656206C2780546910 @default.
• W2059656206 hasConceptScore W2059656206C2780733359 @default.
• W2059656206 hasConceptScore W2059656206C2780841215 @default.
• W2059656206 hasConceptScore W2059656206C55493867 @default.
• W2059656206 hasConceptScore W2059656206C62913699 @default.
• W2059656206 hasConceptScore W2059656206C71315377 @default.
• W2059656206 hasConceptScore W2059656206C71924100 @default.
• W2059656206 hasConceptScore W2059656206C78604142 @default.
• W2059656206 hasIssue "6" @default.
• W2059656206 hasLocation W20596562061 @default.
• W2059656206 hasLocation W20596562062 @default.
• W2059656206 hasOpenAccess W2059656206 @default.
• W2059656206 hasPrimaryLocation W20596562061 @default.
• W2059656206 hasRelatedWork W1965622164 @default.
• W2059656206 hasRelatedWork W1984368109 @default.
• W2059656206 hasRelatedWork W1986503441 @default.
• W2059656206 hasRelatedWork W2018322926 @default.
• W2059656206 hasRelatedWork W2075320018 @default.
• W2059656206 hasRelatedWork W2094766549 @default.
• W2059656206 hasRelatedWork W2095525038 @default.
• W2059656206 hasRelatedWork W2105829092 @default.
• W2059656206 hasRelatedWork W2153745738 @default.

• next