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- W2059657376 abstract "Abstract Nicotine is capable of influencing cerebral protein metabolism. In adult brain slices incubated in vitro with nicotine, valine incorporation into protein was stimulated. The effect was specific for l -nicotine; d -nicotine decreased incorporation, and nicotinamide or nicotinic acid had no effect. In animals treated in vivo with nicotine there was a tendency towards increased incorporation, but the increase was not significant. Protein synthesis in the immature brain was affected differently from that in the adult brain; valine incorporation in the newborn was significantly inhibited by nicotine both in vitro and in vivo. The variability of the results in adult brain tissue suggests individual differences in sensitivity to nicotine. The decrease in protein synthesis in the newborn may support the findings of others of a delayed development in newborns from animals treated with nicotine during pregnancy, but the effect may not be long lasting since no effect is found in adult tissue. The opposite effects of nicotine on growing, in contrast to adult brain, as also found with effects of malnutrition, indicates that control and pharmacological sensitivity of immature brain protein metabolism differs from that of the adult brain." @default.
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- W2059657376 title "The effect of nicotine on the metabolism of brain proteins" @default.
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- W2059657376 doi "https://doi.org/10.1016/0028-3908(79)90019-4" @default.
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