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• W2059658624 abstract "Angiotensin II (ANG II) increases oxidative stress and is associated with increased risk of sudden cardiac death. The cardiac Na + channel promoter contains elements that confer redox sensitivity. We tested the hypothesis that ANG II-mediated oxidative stress may modulate Na + channel current through altering channel transcription. In H9c2 myocytes treated for 48 h with ANG II (100 nmol/l) or H 2 O 2 (10 μmol/l) showed delayed macroscopic inactivation, increased late current, and 59.6% and 53.8% reductions in Na + current, respectively ( P ≤ 0.01). By quantitative real-time RT-PCR, the cardiac Na + channel (scn5a) mRNA abundance declined by 47.3% ( P < 0.01) in H9c2 myocytes treated for 48 h with 100 nmol/l ANG II. A similar change occurred with 20 μmol/l H 2 O 2 (46.9%, P < 0.01) after 48 h. Comparable effects were seen in acutely isolated ventricular myocytes. The effects of ANG II could be inhibited by prior treatment of H9c2 cells with scavengers of reactive oxygen species or an inhibitor of the NADPH oxidase. Mutation of the scn5a promoter NF-κB binding site prevented decreased activity in response to ANG II and H 2 O 2 . Gel shift and chromosomal immunoprecipitation assays confirmed that nuclear factor (NF)-κB bound to the scn5a promoter in response to ANG II and H 2 O 2 . Overexpression of the p50 subunit of NF-κB in H9c2 cells reduced scn5a mRNA (77.3%, P < 0.01). In conclusion, ANG II can decrease scn5a transcription and current. This effect appears to be through production of H 2 O 2 resulting in NF-κB binding to the Na + channel promoter." @default.
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• W2059658624 date "2008-01-01" @default.
• W2059658624 modified "2023-10-09" @default.
• W2059658624 title "NF-κB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II" @default.
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• W2059658624 doi "https://doi.org/10.1152/ajpcell.00186.2007" @default.
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