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- W2059658907 abstract "<b><i>Background/Aims:</i></b> Dialysis triggers stress reaction, matrix remodeling and endothelial damage, but little is known about the changes it induces on selected heat shock proteins (Hsp90α), adhesion molecules (E-cadherin, sE-selectin), metalloproteinases (MMP-8) and their extracellular inducer (EMMPRIN). The aim of this study was to assess serum concentrations of the above-mentioned parameters in children on chronic dialysis. <b><i>Methods:</i></b> 19 patients on hemodialysis (HD), 22 children on peritoneal dialysis (PD) and 30 age-matched controls were examined. Serum concentrations of parameters were assessed by ELISA. <b><i>Results:</i></b> Hsp90α, MMP-8, EMMPRIN and E-cadherin concentrations were significantly increased in children on dialysis vs. controls and higher levels were in HD than PD patients. There was no difference in the level of sE-selectin between HD and PD modalities. A single HD session diminished Hsp90α, MMP-8, EMMPRIN and E-cadherin values, but had no impact on sE-selectin levels. <b><i>Conclusions:</i></b> Hemodialysis evokes stress reaction, matrix and endothelium destruction, to a greater extent than peritoneal dialysis. Single hemodialysis influences circulating cells rather than endothelial cells." @default.
- W2059658907 created "2016-06-24" @default.
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- W2059658907 date "2014-01-01" @default.
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- W2059658907 title "The Impact of Dialysis Modality on Novel Markers of Stress Reaction, Matrix Remodeling and Endothelial Damage in Children on Chronic Dialysis" @default.
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- W2059658907 doi "https://doi.org/10.1159/000362864" @default.
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