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- W2059660265 abstract "Interaction of neuroleptic drugs with the opiate receptor was investigated by inhibition of the stereospecific binding of 3H-naloxone. Benperidol and pimozide, with IC50's of 0.3–0.5 μM, were more potent than the classical opiates meperidine and propoxyphene. A systematic structure-activity relationship was evident with the basic opiate structure of a benzene and a piperidine ring preserved in active compounds. No correlation between neuroleptic activity and binding to the opiate receptor was demonstrated." @default.
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- W2059660265 title "Butyrophenone influences on the opiate receptor" @default.
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- W2059660265 doi "https://doi.org/10.1016/0014-2999(76)90277-6" @default.
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