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• W2059665779 endingPage "1965" @default.
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• W2059665779 abstract "ABSTRACT Cell polarization and fusion are crucial developmental processes that occur in response to intracellular and extracellular signals. Asexual spores (conidia) of the mold Neurospora crassa differentiate two types of polarized cell protrusions, germ tubes and conidial anastomosis tubes (CATs), which exhibit negative and positive chemotropism, respectively. We provide the first evidence that shared and separate functions of the Rho-type GTPases CDC-42 and RAC-1 regulate these opposite chemotropisms. We demonstrate that RAC-1 is essential for CAT formation and cell fusion, whereas CDC-42 is necessary and sufficient for normal germ tube development. Cdc42-Rac-interactive-binding (CRIB) reporters were constructed to exclusively label locally activated GTP-bound GTPases. Time course analyses showed that repositioning of these activated GTPase clusters within germ tube and CAT tip apices controls directional growth in the absence of a tip-localized vesicle supply center (Spitzenkörper). We propose a model in which the local assembly of a plasma-membrane-associated GTPase–PAK–MAPK signaling platform regulates chemoattractant perception and secretion in order to synchronize oscillatory cell–cell communication and directional CAT tip growth." @default.
• W2059665779 created "2016-06-24" @default.
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• W2059665779 date "2014-05-01" @default.
• W2059665779 modified "2023-10-16" @default.
• W2059665779 title "CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa" @default.
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• W2059665779 doi "https://doi.org/10.1242/jcs.141630" @default.
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