FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059666540> ?p ?o ?g. }

• W2059666540 endingPage "83" @default.
• W2059666540 startingPage "68" @default.
• W2059666540 abstract "Information about M6P/IGF2R and p53 genes in hepatocarcinogenesis is limited and controversial. We tested the loss of heterozygosity (LOH) of M6P/IGF2R and p53 genes in cirrhotic and neoplastic foci in surgically resected livers of 30 patients with hepatocellular carcinoma (HCC). The DNAs extracted from microdissected specimens were used for polymerase-chain-reaction (PCR)-based assay. LOH of the M6P/IGF2R gene in the primary HCCs was detected in 10 of 22 informative cases (45%). In five of these 10 cases (50%), LOH was detected in cirrhotic lesions adjacent to the HCCs. The allelic loss patterns of M6P/IGF2R in liver cirrhosis (LC) were identical to those in the corresponding HCC, suggesting that HCC could develop from one of the cells in which M6P/IGF2R had been lost. Furthermore, LOH of the p53 gene in HCC was detected in 10 (43%) of 23 informative cases, and p53 loss in cirrhotic foci adjacent to HCC was shown in one of the 10 cases (10%). The pattern of allelic loss of the p53 gene in the cirrhotic foci was identical with that in the corresponding tumor. The LOH of the M6P/IGF2R and p53 genes occurred independently in HCCs. LOH of the M6P/IGF2R locus was a relatively frequent and possibly early event in hepatocarcinogenesis, and LOH of the M6P/IGF2R gene and LOH of the p53 gene occurred independently." @default.
• W2059666540 created "2016-06-24" @default.
• W2059666540 creator A5003220233 @default.
• W2059666540 creator A5007672008 @default.
• W2059666540 creator A5022480855 @default.
• W2059666540 creator A5048787856 @default.
• W2059666540 creator A5049196605 @default.
• W2059666540 creator A5058948315 @default.
• W2059666540 creator A5067888213 @default.
• W2059666540 creator A5090384790 @default.
• W2059666540 creator A5091900742 @default.
• W2059666540 date "2001-05-01" @default.
• W2059666540 modified "2023-10-18" @default.
• W2059666540 title "Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma" @default.
• W2059666540 cites W1509029991 @default.
• W2059666540 cites W1552426876 @default.
• W2059666540 cites W1572032955 @default.
• W2059666540 cites W1585869774 @default.
• W2059666540 cites W1597560478 @default.
• W2059666540 cites W165030639 @default.
• W2059666540 cites W1838464786 @default.
• W2059666540 cites W1845252930 @default.
• W2059666540 cites W1862543179 @default.
• W2059666540 cites W1978713319 @default.
• W2059666540 cites W1987340041 @default.
• W2059666540 cites W1987536971 @default.
• W2059666540 cites W1993509712 @default.
• W2059666540 cites W1994545433 @default.
• W2059666540 cites W1996445030 @default.
• W2059666540 cites W2006355664 @default.
• W2059666540 cites W2006383082 @default.
• W2059666540 cites W2009752621 @default.
• W2059666540 cites W2011844018 @default.
• W2059666540 cites W2028027936 @default.
• W2059666540 cites W2028979797 @default.
• W2059666540 cites W2041988832 @default.
• W2059666540 cites W2045764692 @default.
• W2059666540 cites W2047038838 @default.
• W2059666540 cites W2047692862 @default.
• W2059666540 cites W2057876368 @default.
• W2059666540 cites W2074529868 @default.
• W2059666540 cites W2076014957 @default.
• W2059666540 cites W2086397687 @default.
• W2059666540 cites W2090684975 @default.
• W2059666540 cites W2096360449 @default.
• W2059666540 cites W2131197313 @default.
• W2059666540 cites W2134153682 @default.
• W2059666540 cites W2137341964 @default.
• W2059666540 cites W2140984295 @default.
• W2059666540 cites W2141759099 @default.
• W2059666540 cites W2149413790 @default.
• W2059666540 cites W2395530443 @default.
• W2059666540 cites W35099944 @default.
• W2059666540 doi "https://doi.org/10.1016/s1386-6346(00)00130-3" @default.
• W2059666540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11282487" @default.
• W2059666540 hasPublicationYear "2001" @default.
• W2059666540 type Work @default.
• W2059666540 sameAs 2059666540 @default.
• W2059666540 citedByCount "10" @default.
• W2059666540 countsByYear W20596665402014 @default.
• W2059666540 countsByYear W20596665402020 @default.
• W2059666540 crossrefType "journal-article" @default.
• W2059666540 hasAuthorship W2059666540A5003220233 @default.
• W2059666540 hasAuthorship W2059666540A5007672008 @default.
• W2059666540 hasAuthorship W2059666540A5022480855 @default.
• W2059666540 hasAuthorship W2059666540A5048787856 @default.
• W2059666540 hasAuthorship W2059666540A5049196605 @default.
• W2059666540 hasAuthorship W2059666540A5058948315 @default.
• W2059666540 hasAuthorship W2059666540A5067888213 @default.
• W2059666540 hasAuthorship W2059666540A5090384790 @default.
• W2059666540 hasAuthorship W2059666540A5091900742 @default.
• W2059666540 hasConcept C104317684 @default.
• W2059666540 hasConcept C126322002 @default.
• W2059666540 hasConcept C143589142 @default.
• W2059666540 hasConcept C144174609 @default.
• W2059666540 hasConcept C170493617 @default.
• W2059666540 hasConcept C180754005 @default.
• W2059666540 hasConcept C21936154 @default.
• W2059666540 hasConcept C2775960820 @default.
• W2059666540 hasConcept C2777214474 @default.
• W2059666540 hasConcept C2778019345 @default.
• W2059666540 hasConcept C2779314089 @default.
• W2059666540 hasConcept C502942594 @default.
• W2059666540 hasConcept C54355233 @default.
• W2059666540 hasConcept C71924100 @default.
• W2059666540 hasConcept C84597430 @default.
• W2059666540 hasConcept C86803240 @default.
• W2059666540 hasConceptScore W2059666540C104317684 @default.
• W2059666540 hasConceptScore W2059666540C126322002 @default.
• W2059666540 hasConceptScore W2059666540C143589142 @default.
• W2059666540 hasConceptScore W2059666540C144174609 @default.
• W2059666540 hasConceptScore W2059666540C170493617 @default.
• W2059666540 hasConceptScore W2059666540C180754005 @default.
• W2059666540 hasConceptScore W2059666540C21936154 @default.
• W2059666540 hasConceptScore W2059666540C2775960820 @default.
• W2059666540 hasConceptScore W2059666540C2777214474 @default.
• W2059666540 hasConceptScore W2059666540C2778019345 @default.
• W2059666540 hasConceptScore W2059666540C2779314089 @default.

• next