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• W2059668875 abstract "Male mice were administered the organophosphorus insecticide disulfoton (O,O-diethyl S-[2-(ethylthio)ethyl] phosphorodithioate) daily for 14 days at a dosage rate of 10 mg/kg/day. Signs of poisoning disappeared after 5 to 8 days of treatment indicating that the animals had developed tolerance to disulfoton toxicity. Acetylcholinesterase activity was inhibited 75 to 93% in hippocampus, cerebral cortex, striatum, and cerebellum of tolerant animals. Binding of the muscarinic cholinergic antagonist [3H]quinuclidinyl benzilate was significantly decreased in all these brain areas. The decrease was due to a decrease in the number of receptors (B max) without any change in the affinity constant Kd. Sodium-dependent high-affinity choline uptake was unchanged in the hippocampus of tolerant animals. When tested in a single trial passive avoidance task, mice tolerant to disulfoton did not show any difference from controls in 24-hr retention. These results indicate that the decreased number of muscarinic receptors in brain of disulfoton-tolerant animals does not affect their response latencies in a passive avoidance task." @default.
• W2059668875 created "2016-06-24" @default.
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• W2059668875 date "1982-09-01" @default.
• W2059668875 modified "2023-09-27" @default.
• W2059668875 title "Passive avoidance retention in mice tolerant to the organophosphorus insecticide disulfoton" @default.
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• W2059668875 doi "https://doi.org/10.1016/0041-008x(82)90390-8" @default.
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