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- W2059676095 abstract "Several chemicals that are used for manufacturing of rubber were tested for embryotoxicity on three day chicken embryos. Cyclohaxylthiophtalimide was the most potent of the chemicals, with an ED value for the total embryotoxic effect 0.04 μmol (10 μg) per egg. Phtalic anhydride was about ten times less potent, having the total ED50 for total embryotoxicity 0.38 μnol (56μg) per egg. Two esters of phtalic acid, dibutylphtalate and butylbenzylphtalate, instead, were relatively impotent, with ED50 values of about 33 μmolas and 27 μmolas per egg, respectively. Two phosphates, tricresylphosphate and synthetic arylphosphate, were not potent embryotoxic agents in the chick embryos. They had SD50 values of 7.0 μmo Lea (2.6 mg) per egg and 9.5 mg per egg, respectively. Sodium phosphate (NaH2PO4) had the ED50 11 μmolas per egg. Three types of oils were tested, too. A mixture known as “highly aromatic oils” was the most potent, with the ED50 31 μg per egg. 'Low aromatic, paraffin base oils was the next potent, with the ED50 87 μg per egg, while “naphtenic oils” had the ED50 480 μg per egg. Cyclohexylthiophtalimide and phtalic anhydride caused malformations at high frequency. The oils and tricresylphosphate appeared to be efficient teratogens under the experimental conditions used." @default.
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- W2059676095 date "1983-01-01" @default.
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- W2059676095 title "Embryotoxic Effects of Phtalic Acid Derivatives, Phosphates and Aromatic Oils Used in the Manufacturing of Rubber on Three Day Chicken Embryos" @default.
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- W2059676095 doi "https://doi.org/10.3109/01480548309016024" @default.
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