Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059682011> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2059682011 endingPage "637" @default.
- W2059682011 startingPage "633" @default.
- W2059682011 abstract "To report the efficacy, tolerability, and safety of the dopamine agonist pramipexole in a series of 5 patients affected by inherited 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and needing l-3,4 dihydroxyphenylalanine (l-dopa) therapy.Patients included 4 males and 1 female with ages ranging from 2 to 26 years. Their medication included tetrahydrobiopterin (BH4), 5-hydroxytryptophan, l-dopa, carbidopa, selegiline, and entacapone. All experienced residual symptoms of dopamine deficiency, movement and behavioral disability, and complications of l-dopa therapy, associated with fluctuating hyperprolactinemia. Patients had full assessment of clinical and biochemical condition, including evaluation by an adapted Unified Parkinson's Disease Rating Scale (UPDRS) and measurement of plasma prolactin (PRL) and catecholamines, before and after a 6-week trial with pramipexole. Pramipexole was administered twice daily as an adjunct to l-dopa therapy in dosages upwardly titrated, with a concurrent reduction of l-dopa dosage. Clinical follow-up went on for 1 year.Pramipexole was well tolerated by all patients, with marked improvement and stabilization of their clinical picture. The mean improvement on the total UPDRS score was 43% (range 33.3%-55.6%) from baseline. Diurnal profiles of plasma PRL normalized and plasma catecholamine levels lasted unchanged. The daily administrations of l-dopa were curtailed from 3 or 4 to 2, and the l-dopa dosage was reduced up to 40%.The addition of pramipexole to the treatment of 6-pyruvoyl tetrahydropterin synthase deficiency improves the results of l-3,4 dihydroxyphenylalanine therapy. Similar benefits may be expected in other forms of inherited tetrahydrobiopterin deficiency." @default.
- W2059682011 created "2016-06-24" @default.
- W2059682011 creator A5038972460 @default.
- W2059682011 creator A5061269740 @default.
- W2059682011 creator A5072299950 @default.
- W2059682011 creator A5083708071 @default.
- W2059682011 creator A5088369657 @default.
- W2059682011 date "2009-08-24" @default.
- W2059682011 modified "2023-09-25" @default.
- W2059682011 title "Dopamine agonists in 6-pyruvoyl tetrahydropterin synthase deficiency" @default.
- W2059682011 doi "https://doi.org/10.1212/wnl.0b013e3181b38983" @default.
- W2059682011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19704083" @default.
- W2059682011 hasPublicationYear "2009" @default.
- W2059682011 type Work @default.
- W2059682011 sameAs 2059682011 @default.
- W2059682011 citedByCount "29" @default.
- W2059682011 countsByYear W20596820112012 @default.
- W2059682011 countsByYear W20596820112013 @default.
- W2059682011 countsByYear W20596820112014 @default.
- W2059682011 countsByYear W20596820112015 @default.
- W2059682011 countsByYear W20596820112016 @default.
- W2059682011 countsByYear W20596820112018 @default.
- W2059682011 countsByYear W20596820112019 @default.
- W2059682011 countsByYear W20596820112020 @default.
- W2059682011 countsByYear W20596820112021 @default.
- W2059682011 countsByYear W20596820112023 @default.
- W2059682011 crossrefType "journal-article" @default.
- W2059682011 hasAuthorship W2059682011A5038972460 @default.
- W2059682011 hasAuthorship W2059682011A5061269740 @default.
- W2059682011 hasAuthorship W2059682011A5072299950 @default.
- W2059682011 hasAuthorship W2059682011A5083708071 @default.
- W2059682011 hasAuthorship W2059682011A5088369657 @default.
- W2059682011 hasConcept C126322002 @default.
- W2059682011 hasConcept C134018914 @default.
- W2059682011 hasConcept C137183658 @default.
- W2059682011 hasConcept C15744967 @default.
- W2059682011 hasConcept C197934379 @default.
- W2059682011 hasConcept C2776134090 @default.
- W2059682011 hasConcept C2776145790 @default.
- W2059682011 hasConcept C2776754145 @default.
- W2059682011 hasConcept C2776976799 @default.
- W2059682011 hasConcept C2777622882 @default.
- W2059682011 hasConcept C2778258207 @default.
- W2059682011 hasConcept C2778375690 @default.
- W2059682011 hasConcept C2779026782 @default.
- W2059682011 hasConcept C2779134260 @default.
- W2059682011 hasConcept C2779734285 @default.
- W2059682011 hasConcept C2779989193 @default.
- W2059682011 hasConcept C2780304432 @default.
- W2059682011 hasConcept C513476851 @default.
- W2059682011 hasConcept C519581460 @default.
- W2059682011 hasConcept C71924100 @default.
- W2059682011 hasConcept C98274493 @default.
- W2059682011 hasConceptScore W2059682011C126322002 @default.
- W2059682011 hasConceptScore W2059682011C134018914 @default.
- W2059682011 hasConceptScore W2059682011C137183658 @default.
- W2059682011 hasConceptScore W2059682011C15744967 @default.
- W2059682011 hasConceptScore W2059682011C197934379 @default.
- W2059682011 hasConceptScore W2059682011C2776134090 @default.
- W2059682011 hasConceptScore W2059682011C2776145790 @default.
- W2059682011 hasConceptScore W2059682011C2776754145 @default.
- W2059682011 hasConceptScore W2059682011C2776976799 @default.
- W2059682011 hasConceptScore W2059682011C2777622882 @default.
- W2059682011 hasConceptScore W2059682011C2778258207 @default.
- W2059682011 hasConceptScore W2059682011C2778375690 @default.
- W2059682011 hasConceptScore W2059682011C2779026782 @default.
- W2059682011 hasConceptScore W2059682011C2779134260 @default.
- W2059682011 hasConceptScore W2059682011C2779734285 @default.
- W2059682011 hasConceptScore W2059682011C2779989193 @default.
- W2059682011 hasConceptScore W2059682011C2780304432 @default.
- W2059682011 hasConceptScore W2059682011C513476851 @default.
- W2059682011 hasConceptScore W2059682011C519581460 @default.
- W2059682011 hasConceptScore W2059682011C71924100 @default.
- W2059682011 hasConceptScore W2059682011C98274493 @default.
- W2059682011 hasIssue "8" @default.
- W2059682011 hasLocation W20596820111 @default.
- W2059682011 hasLocation W20596820112 @default.
- W2059682011 hasOpenAccess W2059682011 @default.
- W2059682011 hasPrimaryLocation W20596820111 @default.
- W2059682011 hasRelatedWork W2011130816 @default.
- W2059682011 hasRelatedWork W2014392059 @default.
- W2059682011 hasRelatedWork W2059682011 @default.
- W2059682011 hasRelatedWork W2084772795 @default.
- W2059682011 hasRelatedWork W2144881416 @default.
- W2059682011 hasRelatedWork W2411654886 @default.
- W2059682011 hasRelatedWork W2421013896 @default.
- W2059682011 hasRelatedWork W3156619404 @default.
- W2059682011 hasRelatedWork W4308457410 @default.
- W2059682011 hasRelatedWork W4313167688 @default.
- W2059682011 hasVolume "73" @default.
- W2059682011 isParatext "false" @default.
- W2059682011 isRetracted "false" @default.
- W2059682011 magId "2059682011" @default.
- W2059682011 workType "article" @default.