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- W2059685005 abstract "T-cell receptor (TCR) engagement induces the maturation of thymocytes and the activation and proliferation of peripheral T cells through signaling pathways that target several transcription factors. The transcription factor nuclear factor-κB (NF-κB) has an essential role in the activation of mature T cells but the signaling pathway leading from TCR stimulation to NF-κB activation is not well defined. Carma1, Bcl10 and MALT1 are recently identified proteins that have an important and previously unexpected role in antigen receptor-induced NF-κB activation and the control of lymphocyte proliferation. We believe that the recent advances in this field could stimulate research for the development of new immunomodulatory drugs and could lead to a better understanding of the molecular mechanisms underlying the formation of lymphomas and potentially of other immune disorders." @default.
- W2059685005 created "2016-06-24" @default.
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- W2059685005 date "2003-08-01" @default.
- W2059685005 modified "2023-09-26" @default.
- W2059685005 title "TCR-induced NF-κB activation: a crucial role for Carma1, Bcl10 and MALT1" @default.
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- W2059685005 doi "https://doi.org/10.1016/s1471-4906(03)00177-7" @default.
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