FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059686054> ?p ?o ?g. }

• W2059686054 endingPage "e43886" @default.
• W2059686054 startingPage "e43886" @default.
• W2059686054 abstract "Nephrolithiasis is a multi-factorial disease which, in the majority of cases, involves the renal deposition of calcium oxalate. Oxalate is a metabolic end product excreted primarily by the kidney. Previous studies have shown that elevated levels of oxalate are detrimental to the renal epithelial cells; however, oxalate renal epithelial cell interactions are not completely understood. In this study, we utilized an unbiased approach of gene expression profiling using Affymetrix HG_U133_plus2 gene chips to understand the global gene expression changes in human renal epithelial cells [HK-2] after exposure to oxalate. We analyzed the expression of 47,000 transcripts and variants, including 38,500 well characterized human genes, in the HK2 cells after 4 hours and 24 hours of oxalate exposure. Gene expression was compared among replicates as per the Affymetrix statistical program. Gene expression among various groups was compared using various analytical tools, and differentially expressed genes were classified according to the Gene Ontology Functional Category. The results from this study show that oxalate exposure induces significant expression changes in many genes. We show for the first time that oxalate exposure induces as well as shuts off genes differentially. We found 750 up-regulated and 2276 down-regulated genes which have not been reported before. Our results also show that renal cells exposed to oxalate results in the regulation of genes that are associated with specific molecular function, biological processes, and other cellular components. In addition we have identified a set of 20 genes that is differentially regulated by oxalate irrespective of duration of exposure and may be useful in monitoring oxalate nephrotoxicity. Taken together our studies profile global gene expression changes and provide a unique insight into oxalate renal cell interactions and oxalate nephrotoxicity." @default.
• W2059686054 created "2016-06-24" @default.
• W2059686054 creator A5033528355 @default.
• W2059686054 creator A5051788725 @default.
• W2059686054 creator A5053019599 @default.
• W2059686054 creator A5067910048 @default.
• W2059686054 date "2012-09-19" @default.
• W2059686054 modified "2023-09-29" @default.
• W2059686054 title "Genome Wide Analysis of Differentially Expressed Genes in HK-2 Cells, a Line of Human Kidney Epithelial Cells in Response to Oxalate" @default.
• W2059686054 cites W1544923801 @default.
• W2059686054 cites W1636398861 @default.
• W2059686054 cites W1968690146 @default.
• W2059686054 cites W1970156673 @default.
• W2059686054 cites W1988838635 @default.
• W2059686054 cites W2010457940 @default.
• W2059686054 cites W2010583469 @default.
• W2059686054 cites W2016373119 @default.
• W2059686054 cites W2018916300 @default.
• W2059686054 cites W2019424234 @default.
• W2059686054 cites W2027312326 @default.
• W2059686054 cites W2053764917 @default.
• W2059686054 cites W2053992229 @default.
• W2059686054 cites W2056011457 @default.
• W2059686054 cites W2073358942 @default.
• W2059686054 cites W2077366591 @default.
• W2059686054 cites W2084552518 @default.
• W2059686054 cites W2084803755 @default.
• W2059686054 cites W2084938125 @default.
• W2059686054 cites W2092737890 @default.
• W2059686054 cites W2094543097 @default.
• W2059686054 cites W2102330962 @default.
• W2059686054 cites W2151508120 @default.
• W2059686054 cites W2172266524 @default.
• W2059686054 cites W2339751006 @default.
• W2059686054 cites W2404206845 @default.
• W2059686054 cites W2416155544 @default.
• W2059686054 cites W2419328944 @default.
• W2059686054 cites W2464249396 @default.
• W2059686054 cites W2467029317 @default.
• W2059686054 cites W2792164776 @default.
• W2059686054 cites W3171782937 @default.
• W2059686054 cites W72938727 @default.
• W2059686054 cites W130891702 @default.
• W2059686054 doi "https://doi.org/10.1371/journal.pone.0043886" @default.
• W2059686054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3446971" @default.
• W2059686054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23028475" @default.
• W2059686054 hasPublicationYear "2012" @default.
• W2059686054 type Work @default.
• W2059686054 sameAs 2059686054 @default.
• W2059686054 citedByCount "15" @default.
• W2059686054 countsByYear W20596860542014 @default.
• W2059686054 countsByYear W20596860542015 @default.
• W2059686054 countsByYear W20596860542016 @default.
• W2059686054 countsByYear W20596860542017 @default.
• W2059686054 countsByYear W20596860542018 @default.
• W2059686054 countsByYear W20596860542019 @default.
• W2059686054 countsByYear W20596860542022 @default.
• W2059686054 countsByYear W20596860542023 @default.
• W2059686054 crossrefType "journal-article" @default.
• W2059686054 hasAuthorship W2059686054A5033528355 @default.
• W2059686054 hasAuthorship W2059686054A5051788725 @default.
• W2059686054 hasAuthorship W2059686054A5053019599 @default.
• W2059686054 hasAuthorship W2059686054A5067910048 @default.
• W2059686054 hasBestOaLocation W20596860541 @default.
• W2059686054 hasConcept C104317684 @default.
• W2059686054 hasConcept C150194340 @default.
• W2059686054 hasConcept C153911025 @default.
• W2059686054 hasConcept C178790620 @default.
• W2059686054 hasConcept C18431079 @default.
• W2059686054 hasConcept C185592680 @default.
• W2059686054 hasConcept C2776179656 @default.
• W2059686054 hasConcept C2776351790 @default.
• W2059686054 hasConcept C2780091579 @default.
• W2059686054 hasConcept C54355233 @default.
• W2059686054 hasConcept C86803240 @default.
• W2059686054 hasConcept C95444343 @default.
• W2059686054 hasConceptScore W2059686054C104317684 @default.
• W2059686054 hasConceptScore W2059686054C150194340 @default.
• W2059686054 hasConceptScore W2059686054C153911025 @default.
• W2059686054 hasConceptScore W2059686054C178790620 @default.
• W2059686054 hasConceptScore W2059686054C18431079 @default.
• W2059686054 hasConceptScore W2059686054C185592680 @default.
• W2059686054 hasConceptScore W2059686054C2776179656 @default.
• W2059686054 hasConceptScore W2059686054C2776351790 @default.
• W2059686054 hasConceptScore W2059686054C2780091579 @default.
• W2059686054 hasConceptScore W2059686054C54355233 @default.
• W2059686054 hasConceptScore W2059686054C86803240 @default.
• W2059686054 hasConceptScore W2059686054C95444343 @default.
• W2059686054 hasIssue "9" @default.
• W2059686054 hasLocation W20596860541 @default.
• W2059686054 hasLocation W20596860542 @default.
• W2059686054 hasLocation W20596860543 @default.
• W2059686054 hasLocation W20596860544 @default.
• W2059686054 hasOpenAccess W2059686054 @default.
• W2059686054 hasPrimaryLocation W20596860541 @default.
• W2059686054 hasRelatedWork W2009966535 @default.
• W2059686054 hasRelatedWork W2053053668 @default.
• W2059686054 hasRelatedWork W2059686054 @default.

• next