Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059687071> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2059687071 abstract "The present studies were undertaken to examine how the substitution of racemized forms of selected amino acids in synthetic peptides of guinea pig myelin basic protein (GPMBP) would alter the host's immunological ability to recognize such molecules. Using peptides from the 69-84 sequence of GPMBP containing a D-serine at position 70 or 75 (69-84[D-ser70 or D-ser75]) or D-aspartate at position 82 (69-84[D-asp82]), the findings demonstrated that the position of the diastereomer substitution on these neuropeptides was critical with respect to the ability of the immune system to recognize the molecule. Thus substitution of D-asp at position 82 or D-ser at position 75 abrogated the ability of these peptides to induce experimental autoimmune encephalitis and proliferation of host T cells. In contrast, a peptide containing a D-ser70 residue was capable of inducing clinical disease in rats, as well as stimulating T lymphocytes from 69-84-(D-ser70)-injected animals. Moreover, although this D-peptide was shown to share at least some determinant(s) with the 69-84 peptide, the use of 69-84(D-ser70)-stimulated cell lines demonstrated that some epitope(s) unique to this molecule could stimulate CD4+ syngeneic T cells." @default.
- W2059687071 created "2016-06-24" @default.
- W2059687071 creator A5015716675 @default.
- W2059687071 creator A5022245863 @default.
- W2059687071 creator A5069129383 @default.
- W2059687071 creator A5080627622 @default.
- W2059687071 creator A5084690615 @default.
- W2059687071 creator A5091378221 @default.
- W2059687071 date "1990-01-01" @default.
- W2059687071 modified "2023-10-14" @default.
- W2059687071 title "T lymphocytes can recognize determinants unique to neuropeptides of guinea pig myelin basic protein containing a single D-isomer amino acid substitution" @default.
- W2059687071 cites W1898812238 @default.
- W2059687071 cites W1990332976 @default.
- W2059687071 cites W1999368185 @default.
- W2059687071 cites W2013959518 @default.
- W2059687071 cites W2037349488 @default.
- W2059687071 cites W2048443971 @default.
- W2059687071 cites W2060448151 @default.
- W2059687071 cites W2061051739 @default.
- W2059687071 cites W2061706784 @default.
- W2059687071 cites W2066016513 @default.
- W2059687071 cites W2080160473 @default.
- W2059687071 cites W2083825831 @default.
- W2059687071 cites W2084093106 @default.
- W2059687071 cites W2085296726 @default.
- W2059687071 cites W2155951011 @default.
- W2059687071 cites W2320556745 @default.
- W2059687071 cites W2333470577 @default.
- W2059687071 cites W2587538053 @default.
- W2059687071 doi "https://doi.org/10.1002/jnr.490250105" @default.
- W2059687071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1690818" @default.
- W2059687071 hasPublicationYear "1990" @default.
- W2059687071 type Work @default.
- W2059687071 sameAs 2059687071 @default.
- W2059687071 citedByCount "1" @default.
- W2059687071 crossrefType "journal-article" @default.
- W2059687071 hasAuthorship W2059687071A5015716675 @default.
- W2059687071 hasAuthorship W2059687071A5022245863 @default.
- W2059687071 hasAuthorship W2059687071A5069129383 @default.
- W2059687071 hasAuthorship W2059687071A5080627622 @default.
- W2059687071 hasAuthorship W2059687071A5084690615 @default.
- W2059687071 hasAuthorship W2059687071A5091378221 @default.
- W2059687071 hasConcept C104317684 @default.
- W2059687071 hasConcept C118303440 @default.
- W2059687071 hasConcept C11960822 @default.
- W2059687071 hasConcept C134018914 @default.
- W2059687071 hasConcept C147483822 @default.
- W2059687071 hasConcept C167625842 @default.
- W2059687071 hasConcept C170493617 @default.
- W2059687071 hasConcept C185592680 @default.
- W2059687071 hasConcept C195616568 @default.
- W2059687071 hasConcept C203014093 @default.
- W2059687071 hasConcept C2776414213 @default.
- W2059687071 hasConcept C2778609137 @default.
- W2059687071 hasConcept C2779281246 @default.
- W2059687071 hasConcept C2780876595 @default.
- W2059687071 hasConcept C515207424 @default.
- W2059687071 hasConcept C529278444 @default.
- W2059687071 hasConcept C55493867 @default.
- W2059687071 hasConcept C71240020 @default.
- W2059687071 hasConcept C86803240 @default.
- W2059687071 hasConcept C8891405 @default.
- W2059687071 hasConceptScore W2059687071C104317684 @default.
- W2059687071 hasConceptScore W2059687071C118303440 @default.
- W2059687071 hasConceptScore W2059687071C11960822 @default.
- W2059687071 hasConceptScore W2059687071C134018914 @default.
- W2059687071 hasConceptScore W2059687071C147483822 @default.
- W2059687071 hasConceptScore W2059687071C167625842 @default.
- W2059687071 hasConceptScore W2059687071C170493617 @default.
- W2059687071 hasConceptScore W2059687071C185592680 @default.
- W2059687071 hasConceptScore W2059687071C195616568 @default.
- W2059687071 hasConceptScore W2059687071C203014093 @default.
- W2059687071 hasConceptScore W2059687071C2776414213 @default.
- W2059687071 hasConceptScore W2059687071C2778609137 @default.
- W2059687071 hasConceptScore W2059687071C2779281246 @default.
- W2059687071 hasConceptScore W2059687071C2780876595 @default.
- W2059687071 hasConceptScore W2059687071C515207424 @default.
- W2059687071 hasConceptScore W2059687071C529278444 @default.
- W2059687071 hasConceptScore W2059687071C55493867 @default.
- W2059687071 hasConceptScore W2059687071C71240020 @default.
- W2059687071 hasConceptScore W2059687071C86803240 @default.
- W2059687071 hasConceptScore W2059687071C8891405 @default.
- W2059687071 hasLocation W20596870711 @default.
- W2059687071 hasLocation W20596870712 @default.
- W2059687071 hasOpenAccess W2059687071 @default.
- W2059687071 hasPrimaryLocation W20596870711 @default.
- W2059687071 hasRelatedWork W1601253405 @default.
- W2059687071 hasRelatedWork W1854368346 @default.
- W2059687071 hasRelatedWork W1975466850 @default.
- W2059687071 hasRelatedWork W1981944109 @default.
- W2059687071 hasRelatedWork W2006014823 @default.
- W2059687071 hasRelatedWork W2024117381 @default.
- W2059687071 hasRelatedWork W2026137340 @default.
- W2059687071 hasRelatedWork W2037194990 @default.
- W2059687071 hasRelatedWork W2065384285 @default.
- W2059687071 hasRelatedWork W2098447543 @default.
- W2059687071 isParatext "false" @default.
- W2059687071 isRetracted "false" @default.
- W2059687071 magId "2059687071" @default.
- W2059687071 workType "article" @default.