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- W2059688422 abstract "Fortified hamster and rat liver microsomes bind the carcinogen aflatoxin B1 (AFB1), but not its much less carcinogenic 2,3-dihydro derivative (aflatoxin B2), to RNA in vitro. Mild acid hydrolysis of the RNA-AFB1 adduct yields a product indistinguishable from synthetic 2,3-dihydro-2,3-dihydroxy-AFB1 in (a) its UV absorption spectra in neutral and alkaline solution, (b) its thin layer chromatography in several solvent systems, and (c) the mass spectra of the acetonide and diacetyl derivatives. AFB1-2,3-oxide is the probable reactive precursor of the RNA-AFB1 adduct. This epoxide merits consideration as a candidate ultimate carcinogenic metabolite of AFB1." @default.
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- W2059688422 date "1973-08-01" @default.
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- W2059688422 title "2,3-Dihydro-2,3-dihydroxy-aflatoxin B1: An acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro" @default.
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- W2059688422 doi "https://doi.org/10.1016/0006-291x(73)90601-3" @default.
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