FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059690859> ?p ?o ?g. }

• W2059690859 endingPage "e1040" @default.
• W2059690859 startingPage "e1040" @default.
• W2059690859 abstract "Background Nematode polyprotein allergens (NPAs) are an unusual class of lipid-binding proteins found only in nematodes. They are synthesized as large, tandemly repetitive polyproteins that are post-translationally cleaved into multiple copies of small lipid binding proteins with virtually identical fatty acid and retinol (Vitamin A)-binding characteristics. They are probably central to transport and distribution of small hydrophobic compounds between the tissues of nematodes, and may play key roles in nutrient scavenging, immunomodulation, and IgE antibody-based responses in infection. In some species the repeating units are diverse in amino acid sequence, but, in ascarid and filarial nematodes, many of the units are identical or near-identical. ABA-1A is the most common repeating unit of the NPA of Ascaris suum, and is closely similar to that of Ascaris lumbricoides, the large intestinal roundworm of humans. Immune responses to NPAs have been associated with naturally-acquired resistance to infection in humans, and the immune repertoire to them is under strict genetic control. Methodology/Principal Findings The solution structure of ABA-1A was determined by protein nuclear magnetic resonance spectroscopy. The protein adopts a novel seven-helical fold comprising a long central helix that participates in two hollow four-helical bundles on either side. Discrete hydrophobic ligand-binding pockets are found in the N-terminal and C-terminal bundles, and the amino acid sidechains affected by ligand (fatty acid) binding were identified. Recombinant ABA-1A contains tightly-bound ligand(s) of bacterial culture origin in one of its binding sites. Conclusions/Significance This is the first mature, post-translationally processed, unit of a naturally-occurring tandemly-repetitive polyprotein to be structurally characterized from any source, and it belongs to a new structural class. NPAs have no counterparts in vertebrates, so represent potential targets for drug or immunological intervention. The nature of the (as yet) unidentified bacterial ligand(s) may be pertinent to this, as will our characterization of the unusual binding sites." @default.
• W2059690859 created "2016-06-24" @default.
• W2059690859 creator A5004716180 @default.
• W2059690859 creator A5006377097 @default.
• W2059690859 creator A5009582195 @default.
• W2059690859 creator A5019916986 @default.
• W2059690859 creator A5030104820 @default.
• W2059690859 creator A5031887334 @default.
• W2059690859 creator A5076963127 @default.
• W2059690859 date "2011-04-19" @default.
• W2059690859 modified "2023-10-18" @default.
• W2059690859 title "Solution Structure of a Repeated Unit of the ABA-1 Nematode Polyprotein Allergen of Ascaris Reveals a Novel Fold and Two Discrete Lipid-Binding Sites" @default.
• W2059690859 cites W1508636766 @default.
• W2059690859 cites W1530913262 @default.
• W2059690859 cites W1578814306 @default.
• W2059690859 cites W1590101666 @default.
• W2059690859 cites W1731585115 @default.
• W2059690859 cites W1928735362 @default.
• W2059690859 cites W1963604403 @default.
• W2059690859 cites W1972699470 @default.
• W2059690859 cites W1973621188 @default.
• W2059690859 cites W1974326515 @default.
• W2059690859 cites W1975459052 @default.
• W2059690859 cites W1977791042 @default.
• W2059690859 cites W1978203540 @default.
• W2059690859 cites W1979016062 @default.
• W2059690859 cites W1979419170 @default.
• W2059690859 cites W1980284892 @default.
• W2059690859 cites W1980950609 @default.
• W2059690859 cites W1987120082 @default.
• W2059690859 cites W1989014138 @default.
• W2059690859 cites W1995017064 @default.
• W2059690859 cites W2000612239 @default.
• W2059690859 cites W2001733512 @default.
• W2059690859 cites W2002071039 @default.
• W2059690859 cites W2012517365 @default.
• W2059690859 cites W2014477053 @default.
• W2059690859 cites W2016353500 @default.
• W2059690859 cites W2021876859 @default.
• W2059690859 cites W2022058405 @default.
• W2059690859 cites W2024168295 @default.
• W2059690859 cites W2031261000 @default.
• W2059690859 cites W2031431898 @default.
• W2059690859 cites W2041449451 @default.
• W2059690859 cites W2041803234 @default.
• W2059690859 cites W2043734506 @default.
• W2059690859 cites W2045446243 @default.
• W2059690859 cites W2046096313 @default.
• W2059690859 cites W2054843238 @default.
• W2059690859 cites W2058881180 @default.
• W2059690859 cites W2058995637 @default.
• W2059690859 cites W2062557777 @default.
• W2059690859 cites W2069602336 @default.
• W2059690859 cites W2069673822 @default.
• W2059690859 cites W2069942730 @default.
• W2059690859 cites W2070534813 @default.
• W2059690859 cites W2075769561 @default.
• W2059690859 cites W2075883751 @default.
• W2059690859 cites W2077776336 @default.
• W2059690859 cites W2078040293 @default.
• W2059690859 cites W2079040627 @default.
• W2059690859 cites W2083422909 @default.
• W2059690859 cites W2083458172 @default.
• W2059690859 cites W2086862822 @default.
• W2059690859 cites W2090878038 @default.
• W2059690859 cites W2092650701 @default.
• W2059690859 cites W2102916539 @default.
• W2059690859 cites W2103794058 @default.
• W2059690859 cites W2104107874 @default.
• W2059690859 cites W2112103709 @default.
• W2059690859 cites W2113435825 @default.
• W2059690859 cites W2118813986 @default.
• W2059690859 cites W2119034696 @default.
• W2059690859 cites W2123448870 @default.
• W2059690859 cites W2125874989 @default.
• W2059690859 cites W2127516852 @default.
• W2059690859 cites W2138818601 @default.
• W2059690859 cites W2142989423 @default.
• W2059690859 cites W2144889711 @default.
• W2059690859 cites W2148521301 @default.
• W2059690859 cites W2156034391 @default.
• W2059690859 cites W2158998808 @default.
• W2059690859 cites W2169707043 @default.
• W2059690859 cites W348533031 @default.
• W2059690859 cites W4248954029 @default.
• W2059690859 doi "https://doi.org/10.1371/journal.pntd.0001040" @default.
• W2059690859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079579" @default.
• W2059690859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21526216" @default.
• W2059690859 hasPublicationYear "2011" @default.
• W2059690859 type Work @default.
• W2059690859 sameAs 2059690859 @default.
• W2059690859 citedByCount "27" @default.
• W2059690859 countsByYear W20596908592012 @default.
• W2059690859 countsByYear W20596908592013 @default.
• W2059690859 countsByYear W20596908592014 @default.
• W2059690859 countsByYear W20596908592015 @default.
• W2059690859 countsByYear W20596908592016 @default.
• W2059690859 countsByYear W20596908592017 @default.

• next