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• W2059691505 abstract "The rapid and sensitive detection and characterization of human viruses and bacteriophage is extremely important in a variety of fields, such as medical diagnostics, immunology and vaccine research, and environmental contamination and quality control. We introduce an optical detection scheme for real-time and label-free detection of human viruses and bacteriophage as small as ~24 nm in radius. Combining the advantages of heterodyne interferometry and dark-field microscopy, this label-free method enables us to detect and characterize various biological nanoparticles with unsurpassed sensitivity and selectivity. We demonstrate the high sensitivity and precision of the method by analyzing a mixture containing HIV virus and bacteriophage. The method also resolves the distribution of small nano-impurities (~20-30 nm) in clinically relevant virus samples." @default.
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• W2059691505 date "2012-01-01" @default.
• W2059691505 modified "2023-09-23" @default.
• W2059691505 title "Real-time optical detection of single human and bacterial viruses based on dark-field interferometry" @default.
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• W2059691505 doi "https://doi.org/10.1016/j.bios.2011.11.025" @default.
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