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• W2059691908 abstract "Recently, we disclosed that KIAA1199-mediated hyaluronan (HA) depolymerization requires an acidic cellular microenvironment (e.g. clathrin-coated vesicles or early endosomes), but no information about the structural basis underlying the cellular targeting and functional modification of KIAA1199 was available. Here, we show that the cleavage of N-terminal 30 amino acids occurs in functionally matured KIAA1199, and the deletion of the N-terminal portion results in altered intracellular trafficking of the molecule and loss of cellular HA depolymerization. These results suggest that the N-terminal portion of KIAA1199 functions as a cleavable signal sequence required for proper KIAA1199 translocation and KIAA1199-mediated HA depolymerization." @default.
• W2059691908 created "2016-06-24" @default.
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• W2059691908 date "2013-11-20" @default.
• W2059691908 modified "2023-10-15" @default.
• W2059691908 title "N-terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199" @default.
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• W2059691908 doi "https://doi.org/10.1016/j.febslet.2013.11.017" @default.
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