Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059692709> ?p ?o ?g. }
- W2059692709 endingPage "607" @default.
- W2059692709 startingPage "600" @default.
- W2059692709 abstract "ABSTRACT We have selected for resistance to etravirine (ETR) and efavirenz (EFV) in tissue culture using three subtype B, three subtype C, and two CRF02_AG clinical isolates, grown in cord blood mononuclear cells. Genotypic analysis was performed at baseline and at various weeks of selection. Phenotypic resistance in regard to ETR, EFV, and nevirapine (NVP) was evaluated at weeks 25 to 30 for all ETR-selected viruses and in viral clones that contained specific resistance mutations that were inserted by site-directed mutagenesis into pNL-4.3 and AG plasmids. The results show that ETR selected mutations at positions V90I, K101Q, E138K, V179D/E/F, Y181C, V189I, G190E, H221H/Y, and M230L and that E138K was the first of these to emerge in most instances. The time to the emergence of resistance was longer in the case of ETR (18 weeks) compared to EFV (11 weeks), and no differences in the patterns of emergent mutations could be documented between the B and non-B subtypes. Viral clones containing E138K displayed low-level phenotypic resistance to ETR (3.8-fold) and modestly impaired replication capacity (2-fold) compared to wild-type virus. ETR-selected virus showed a high degree of cross-resistance to NVP but not to EFV. We identified K101Q, E138K, V179E, V189I, G190E, and H221Y as mutations not included among the 17 currently recognized resistance-associated mutations for ETR." @default.
- W2059692709 created "2016-06-24" @default.
- W2059692709 creator A5029881635 @default.
- W2059692709 creator A5035584213 @default.
- W2059692709 creator A5042954024 @default.
- W2059692709 creator A5052154929 @default.
- W2059692709 creator A5067324604 @default.
- W2059692709 creator A5082776171 @default.
- W2059692709 creator A5089407510 @default.
- W2059692709 date "2011-02-01" @default.
- W2059692709 modified "2023-10-18" @default.
- W2059692709 title "Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes" @default.
- W2059692709 cites W120421073 @default.
- W2059692709 cites W1494105110 @default.
- W2059692709 cites W1635485592 @default.
- W2059692709 cites W1980214158 @default.
- W2059692709 cites W198200742 @default.
- W2059692709 cites W1985824057 @default.
- W2059692709 cites W1995559092 @default.
- W2059692709 cites W1999838828 @default.
- W2059692709 cites W2007434340 @default.
- W2059692709 cites W2015857747 @default.
- W2059692709 cites W2027465011 @default.
- W2059692709 cites W2029164328 @default.
- W2059692709 cites W2030633257 @default.
- W2059692709 cites W2053570554 @default.
- W2059692709 cites W2056708520 @default.
- W2059692709 cites W2058498750 @default.
- W2059692709 cites W2063865579 @default.
- W2059692709 cites W2073166517 @default.
- W2059692709 cites W2074546506 @default.
- W2059692709 cites W2079791093 @default.
- W2059692709 cites W2081539383 @default.
- W2059692709 cites W2084136477 @default.
- W2059692709 cites W2087144560 @default.
- W2059692709 cites W2092745642 @default.
- W2059692709 cites W2097847166 @default.
- W2059692709 cites W2106491426 @default.
- W2059692709 cites W2109193129 @default.
- W2059692709 cites W2119433625 @default.
- W2059692709 cites W2120602370 @default.
- W2059692709 cites W2121179908 @default.
- W2059692709 cites W2127518061 @default.
- W2059692709 cites W2135113708 @default.
- W2059692709 cites W2139034522 @default.
- W2059692709 cites W2147099225 @default.
- W2059692709 cites W2155267141 @default.
- W2059692709 cites W2157722508 @default.
- W2059692709 cites W2167698825 @default.
- W2059692709 cites W2168054393 @default.
- W2059692709 cites W2170383569 @default.
- W2059692709 cites W2171350823 @default.
- W2059692709 cites W2172130850 @default.
- W2059692709 cites W2172212187 @default.
- W2059692709 cites W2330399120 @default.
- W2059692709 cites W2404779005 @default.
- W2059692709 cites W55384331 @default.
- W2059692709 doi "https://doi.org/10.1128/aac.01192-10" @default.
- W2059692709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3028807" @default.
- W2059692709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21135184" @default.
- W2059692709 hasPublicationYear "2011" @default.
- W2059692709 type Work @default.
- W2059692709 sameAs 2059692709 @default.
- W2059692709 citedByCount "59" @default.
- W2059692709 countsByYear W20596927092012 @default.
- W2059692709 countsByYear W20596927092013 @default.
- W2059692709 countsByYear W20596927092014 @default.
- W2059692709 countsByYear W20596927092015 @default.
- W2059692709 countsByYear W20596927092016 @default.
- W2059692709 countsByYear W20596927092017 @default.
- W2059692709 countsByYear W20596927092018 @default.
- W2059692709 countsByYear W20596927092019 @default.
- W2059692709 countsByYear W20596927092020 @default.
- W2059692709 countsByYear W20596927092021 @default.
- W2059692709 countsByYear W20596927092022 @default.
- W2059692709 countsByYear W20596927092023 @default.
- W2059692709 crossrefType "journal-article" @default.
- W2059692709 hasAuthorship W2059692709A5029881635 @default.
- W2059692709 hasAuthorship W2059692709A5035584213 @default.
- W2059692709 hasAuthorship W2059692709A5042954024 @default.
- W2059692709 hasAuthorship W2059692709A5052154929 @default.
- W2059692709 hasAuthorship W2059692709A5067324604 @default.
- W2059692709 hasAuthorship W2059692709A5082776171 @default.
- W2059692709 hasAuthorship W2059692709A5089407510 @default.
- W2059692709 hasBestOaLocation W20596927091 @default.
- W2059692709 hasConcept C104317684 @default.
- W2059692709 hasConcept C127716648 @default.
- W2059692709 hasConcept C135763542 @default.
- W2059692709 hasConcept C140704245 @default.
- W2059692709 hasConcept C142462285 @default.
- W2059692709 hasConcept C153911025 @default.
- W2059692709 hasConcept C156719811 @default.
- W2059692709 hasConcept C159047783 @default.
- W2059692709 hasConcept C16318435 @default.
- W2059692709 hasConcept C2522874641 @default.
- W2059692709 hasConcept C2780345285 @default.
- W2059692709 hasConcept C2781432083 @default.
- W2059692709 hasConcept C2993143319 @default.