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• W2059696554 startingPage "3461" @default.
• W2059696554 abstract "Research into developing dual modality probes enabled for magnetic resonance imaging (MRI) and positron emission tomography (PET) has been on the rise recently due to the potential to combine the high resolution of MRI and the high sensitivity of PET. Current synthesis techniques for developing multimodal probes is largely hindered in part by prolonged reaction times during radioisotope incorporation—leading to a weakening of the radioactivity. Along with a time-efficient synthesis, the resulting products must fit within a critical size range (between 20 and 100 nm) to increase blood retention time. In this work, we describe a novel, rapid, microwave-based synthesis technique to grow dextran-coated iron oxide nanoparticles doped with copper (DIO/Cu). Traditional methods for coprecipitation of dextran-coated iron oxide nanoparticles require refluxing for 2 h and result in approximately 50 nm diameter particles. We demonstrate that microwave synthesis can produce 50 nm nanoparticles with 5 min of heating. We discuss the various parameters used in the microwave synthesis protocol to vary the size distribution of DIO/Cu and demonstrate the successful incorporation of 64Cu into these particles with the aim of future use for dual-mode MR/PET imaging." @default.
• W2059696554 created "2016-06-24" @default.
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• W2059696554 date "2012-03-30" @default.
• W2059696554 modified "2023-09-30" @default.
• W2059696554 title "Rapid Size-Controlled Synthesis of Dextran-Coated, ⁶⁴Cu-Doped Iron Oxide Nanoparticles" @default.
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• W2059696554 doi "https://doi.org/10.1021/nn300494k" @default.
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