FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059699128> ?p ?o ?g. }

• W2059699128 endingPage "917" @default.
• W2059699128 startingPage "905" @default.
• W2059699128 abstract "Chemotherapy of brain tumors remains a big challenge owing to the low drug transport across the blood-brain barrier (BBB), multidrug resistance (MDR), and poor penetration into the tumor tissue. We developed a novel dual-targeting liposomal carrier that enabled drug to transport across the BBB and then target the brain tumor. In the dual-targeting liposomal carrier, tamoxifen (TAM) was incorporated into the lipid bilayer membrane of liposomes and wheat germ agglutinin (WGA) was conjugated to the liposomes' surface. Topotecan was then loaded into the above liposomes. In vitro, topotecan liposomes modified with TAM and WGA were applied to the glioma cells, BBB model, and avascular C6 glioma spheroids, respectively. In vivo, they were systemically administered via vein to brain C6 glioma-bearing rats. In view of the microtiter tetrazolium (MTT) results, topotecan liposomes modified with TAM and WGA exhibited a significant inhibitory effect compared to unmodified topotecan liposomes, suggesting that TAM plus WGA contributed strong drug delivery effects into the brain tumor cells after direct drug exposure. In the experiments of drug transport across the BBB model following drug exposure to tumor cells, topotecan liposomes modified with TAM and WGA exhibited the most robust dual-targeting effects: crossing the BBB and then targeting brain tumor cells. Similar strong activity was found in the reduction of C6 glioma tumor spheroid volume and in the apoptosis of the spheroids. In the brain tumor-bearing rats, the dual-targeting effects of topotecan liposomes modified with TAM and WGA could be evidently observed, resulting in a significant improvement in the overall survival of the brain tumor-bearing rats compared with free topotecan and topotecan liposomes. Moreover, results from an extended treatment group indicated that the survival could be further significantly enhanced, indicating that an extended chemotherapy with topotecan liposomes modified with TAM and WGA would be beneficial for treatment. The dual-targeting effects in vivo of topotecan liposomes modified with TAM and WGA could be related to an enhanced effect by TAM via inhibiting efflux of MDR proteins in the BBB and the brain tumor, and an enhanced effect by WGA via endocytosis in the BBB and in the brain tumor. In conclusion, topotecan liposomes modified with TAM and WGA significantly improve topotecan transport across the blood-brain barrier and the survival of brain tumor-bearing animals, showing dual-targeting effects. These findings would encourage further developments of noninvasive therapy for brain tumor." @default.
• W2059699128 created "2016-06-24" @default.
• W2059699128 creator A5000168358 @default.
• W2059699128 creator A5014480322 @default.
• W2059699128 creator A5016622484 @default.
• W2059699128 creator A5018158708 @default.
• W2059699128 creator A5026429874 @default.
• W2059699128 creator A5037982951 @default.
• W2059699128 creator A5039837606 @default.
• W2059699128 creator A5044867102 @default.
• W2059699128 creator A5047506452 @default.
• W2059699128 creator A5049521464 @default.
• W2059699128 creator A5068028253 @default.
• W2059699128 creator A5069362421 @default.
• W2059699128 creator A5077683891 @default.
• W2059699128 creator A5085553122 @default.
• W2059699128 creator A5086664284 @default.
• W2059699128 date "2009-04-17" @default.
• W2059699128 modified "2023-10-17" @default.
• W2059699128 title "Dual-Targeting Topotecan Liposomes Modified with Tamoxifen and Wheat Germ Agglutinin Significantly Improve Drug Transport across the Blood−Brain Barrier and Survival of Brain Tumor-Bearing Animals" @default.
• W2059699128 cites W1965329272 @default.
• W2059699128 cites W1969388062 @default.
• W2059699128 cites W1972924617 @default.
• W2059699128 cites W1976214499 @default.
• W2059699128 cites W1997712655 @default.
• W2059699128 cites W2009081910 @default.
• W2059699128 cites W2013495726 @default.
• W2059699128 cites W2015541518 @default.
• W2059699128 cites W2018101112 @default.
• W2059699128 cites W2018658803 @default.
• W2059699128 cites W2020216724 @default.
• W2059699128 cites W2023300542 @default.
• W2059699128 cites W2023611106 @default.
• W2059699128 cites W2024787650 @default.
• W2059699128 cites W2027590553 @default.
• W2059699128 cites W2031483215 @default.
• W2059699128 cites W2043513427 @default.
• W2059699128 cites W2062822419 @default.
• W2059699128 cites W2063954663 @default.
• W2059699128 cites W2069661123 @default.
• W2059699128 cites W2076784218 @default.
• W2059699128 cites W2077216169 @default.
• W2059699128 cites W2079146778 @default.
• W2059699128 cites W2083653139 @default.
• W2059699128 cites W2087799951 @default.
• W2059699128 cites W2096391616 @default.
• W2059699128 cites W2096570138 @default.
• W2059699128 cites W2101657078 @default.
• W2059699128 cites W2106762675 @default.
• W2059699128 cites W2110790042 @default.
• W2059699128 cites W2111420064 @default.
• W2059699128 cites W2115072974 @default.
• W2059699128 cites W2117553516 @default.
• W2059699128 cites W2126354472 @default.
• W2059699128 cites W2137210176 @default.
• W2059699128 cites W2138502119 @default.
• W2059699128 cites W2139008103 @default.
• W2059699128 cites W2141151991 @default.
• W2059699128 cites W2165824272 @default.
• W2059699128 cites W2168019328 @default.
• W2059699128 cites W4243866615 @default.
• W2059699128 doi "https://doi.org/10.1021/mp800218q" @default.
• W2059699128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19344115" @default.
• W2059699128 hasPublicationYear "2009" @default.
• W2059699128 type Work @default.
• W2059699128 sameAs 2059699128 @default.
• W2059699128 citedByCount "133" @default.
• W2059699128 countsByYear W20596991282012 @default.
• W2059699128 countsByYear W20596991282013 @default.
• W2059699128 countsByYear W20596991282014 @default.
• W2059699128 countsByYear W20596991282015 @default.
• W2059699128 countsByYear W20596991282016 @default.
• W2059699128 countsByYear W20596991282017 @default.
• W2059699128 countsByYear W20596991282018 @default.
• W2059699128 countsByYear W20596991282019 @default.
• W2059699128 countsByYear W20596991282020 @default.
• W2059699128 countsByYear W20596991282021 @default.
• W2059699128 countsByYear W20596991282022 @default.
• W2059699128 countsByYear W20596991282023 @default.
• W2059699128 crossrefType "journal-article" @default.
• W2059699128 hasAuthorship W2059699128A5000168358 @default.
• W2059699128 hasAuthorship W2059699128A5014480322 @default.
• W2059699128 hasAuthorship W2059699128A5016622484 @default.
• W2059699128 hasAuthorship W2059699128A5018158708 @default.
• W2059699128 hasAuthorship W2059699128A5026429874 @default.
• W2059699128 hasAuthorship W2059699128A5037982951 @default.
• W2059699128 hasAuthorship W2059699128A5039837606 @default.
• W2059699128 hasAuthorship W2059699128A5044867102 @default.
• W2059699128 hasAuthorship W2059699128A5047506452 @default.
• W2059699128 hasAuthorship W2059699128A5049521464 @default.
• W2059699128 hasAuthorship W2059699128A5068028253 @default.
• W2059699128 hasAuthorship W2059699128A5069362421 @default.
• W2059699128 hasAuthorship W2059699128A5077683891 @default.
• W2059699128 hasAuthorship W2059699128A5085553122 @default.
• W2059699128 hasAuthorship W2059699128A5086664284 @default.
• W2059699128 hasConcept C126322002 @default.
• W2059699128 hasConcept C142724271 @default.
• W2059699128 hasConcept C178790620 @default.

• next