Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059699817> ?p ?o ?g. }
- W2059699817 endingPage "35" @default.
- W2059699817 startingPage "27" @default.
- W2059699817 abstract "Clonal chromosome abnormalities can be detected in approximately 50% of patients with chronic lymphocytic leukemia (CLL). The most common changes are trisomy 12, followed by structural abnormalities of 13q, 11q, 6q, and 14q. By fluorescence in situ hybridization (FISH), these aberrations can be demonstrated even in cases with insufficient mitotic yield or a normal karyotype. The biologic consequences of trisomy 12 are unknown, but a gene dosage effect is suspected and studies on partial trisomy 12 indicate that the region 12q13 to 12q22 might be of particular pathogenetic importance. Trisomy 12 is strongly associated with atypical lymphocyte morphology and seems to be a secondary event in leukemogenesis, as shown by combined immunophenotyping and interphase FISH. Structural abnormalities of 13q frequently involve hetero- and homozygous deletions of a region in 13q14, distal to the retinoblastoma gene, which may be the site of a tumor suppressor gene. In contrast to a normal karyotype or structural changes of 13q, complex karyotypic abnormalities, high percentage of abnormal metaphases, trisomy 12 and structural changes involving the P53 tumor suppressor gene on 17p13 are adverse prognostic indicators. Cytogenetic and molecular findings provide important diagnostic, clinical, and prognostic information which can contribute to treatment decisions and follow-up of CLL patients." @default.
- W2059699817 created "2016-06-24" @default.
- W2059699817 creator A5003884581 @default.
- W2059699817 creator A5006829635 @default.
- W2059699817 creator A5013171926 @default.
- W2059699817 creator A5052479430 @default.
- W2059699817 creator A5068156537 @default.
- W2059699817 creator A5085058484 @default.
- W2059699817 date "1997-03-01" @default.
- W2059699817 modified "2023-10-15" @default.
- W2059699817 title "Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications" @default.
- W2059699817 cites W146673805 @default.
- W2059699817 cites W1484886449 @default.
- W2059699817 cites W1525811283 @default.
- W2059699817 cites W154103547 @default.
- W2059699817 cites W1552162287 @default.
- W2059699817 cites W167225159 @default.
- W2059699817 cites W1766897881 @default.
- W2059699817 cites W1933514140 @default.
- W2059699817 cites W1964742152 @default.
- W2059699817 cites W1973737876 @default.
- W2059699817 cites W1975213851 @default.
- W2059699817 cites W1977382048 @default.
- W2059699817 cites W1993659376 @default.
- W2059699817 cites W1996865511 @default.
- W2059699817 cites W1998679425 @default.
- W2059699817 cites W2006486191 @default.
- W2059699817 cites W2010667317 @default.
- W2059699817 cites W2012705583 @default.
- W2059699817 cites W2017374245 @default.
- W2059699817 cites W2018298258 @default.
- W2059699817 cites W2024047179 @default.
- W2059699817 cites W2028651727 @default.
- W2059699817 cites W2034159334 @default.
- W2059699817 cites W2036128327 @default.
- W2059699817 cites W2037297694 @default.
- W2059699817 cites W2040149360 @default.
- W2059699817 cites W2047340111 @default.
- W2059699817 cites W2056163856 @default.
- W2059699817 cites W2057523745 @default.
- W2059699817 cites W2057796341 @default.
- W2059699817 cites W2059558080 @default.
- W2059699817 cites W2066668872 @default.
- W2059699817 cites W2086858152 @default.
- W2059699817 cites W2086950890 @default.
- W2059699817 cites W2088862005 @default.
- W2059699817 cites W2093009930 @default.
- W2059699817 cites W2095387136 @default.
- W2059699817 cites W2099189308 @default.
- W2059699817 cites W2107202569 @default.
- W2059699817 cites W2110096864 @default.
- W2059699817 cites W2111369542 @default.
- W2059699817 cites W2116507138 @default.
- W2059699817 cites W2126804205 @default.
- W2059699817 cites W2129856600 @default.
- W2059699817 cites W2134774489 @default.
- W2059699817 cites W2135078091 @default.
- W2059699817 cites W2157198284 @default.
- W2059699817 cites W2162924223 @default.
- W2059699817 cites W2164041097 @default.
- W2059699817 cites W2198154538 @default.
- W2059699817 cites W2288651330 @default.
- W2059699817 cites W2317615904 @default.
- W2059699817 cites W2326221689 @default.
- W2059699817 cites W2340403458 @default.
- W2059699817 cites W2415954505 @default.
- W2059699817 cites W2417342053 @default.
- W2059699817 cites W2443401866 @default.
- W2059699817 cites W288922733 @default.
- W2059699817 cites W3148859371 @default.
- W2059699817 cites W4253349936 @default.
- W2059699817 cites W4254284752 @default.
- W2059699817 cites W4255180194 @default.
- W2059699817 cites W4255917959 @default.
- W2059699817 cites W474796 @default.
- W2059699817 doi "https://doi.org/10.1016/s0165-4608(96)00246-4" @default.
- W2059699817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9078288" @default.
- W2059699817 hasPublicationYear "1997" @default.
- W2059699817 type Work @default.
- W2059699817 sameAs 2059699817 @default.
- W2059699817 citedByCount "73" @default.
- W2059699817 countsByYear W20596998172012 @default.
- W2059699817 countsByYear W20596998172013 @default.
- W2059699817 countsByYear W20596998172014 @default.
- W2059699817 countsByYear W20596998172016 @default.
- W2059699817 countsByYear W20596998172017 @default.
- W2059699817 countsByYear W20596998172018 @default.
- W2059699817 countsByYear W20596998172019 @default.
- W2059699817 countsByYear W20596998172020 @default.
- W2059699817 countsByYear W20596998172021 @default.
- W2059699817 countsByYear W20596998172023 @default.
- W2059699817 crossrefType "journal-article" @default.
- W2059699817 hasAuthorship W2059699817A5003884581 @default.
- W2059699817 hasAuthorship W2059699817A5006829635 @default.
- W2059699817 hasAuthorship W2059699817A5013171926 @default.
- W2059699817 hasAuthorship W2059699817A5052479430 @default.
- W2059699817 hasAuthorship W2059699817A5068156537 @default.
- W2059699817 hasAuthorship W2059699817A5085058484 @default.